Citation: Lei LI, Feng LIU, Xiang Xu KONG, Shun SU, Ke An LI. Liquid-liquid Extraction System Based on Non-ionic Surfactant-salt-H₂O and Mechanism of Drug Extraction[J]. Chinese Chemical Letters, ;2002, 13(4): 349-350. shu

Liquid-liquid Extraction System Based on Non-ionic Surfactant-salt-H₂O and Mechanism of Drug Extraction

Lei LI ² ,
Feng LIU ¹ ,
Xiang Xu KONG ¹ ,
Shun SU ¹ ,
Ke An LI ¹

1.
College of Chemistry and Molecular Engineering, Peking University, Beijing 100871;
2.
Department of Chemistry, Gannan Teachers College, Ganzhou 341000

Received Date: 29 June 2001

Extraction behavior of chlorpromazine hydrochloride (CPZ) and procaine hydro-chloride (PCN) in the system described in the title was studied.Research shows that the extraction efficiency of CPZ can amount to 96% by twice extraction,while that of PCN is 77%.This system produces the distribution coefficients (K_D) of 12.3 and 2.6 respectively for CPZ and PCN.Extraction mechanism is deduced according to ultraviolet and molecular fluorescence spectra variation of the drugs in the system studied.
- Non-ionic surfactant-salt-H₂O extraction system,
- polyethylene glycol-1000,
- chlor-promazine hydrochloride,
- procaine hydrochloride,
- mechanism of extraction
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