Citation: Hong Yu ZHANG. Scavenging Effect of Perylenequinone Hydroxyls on Free Radicals:A Theoretical Study[J]. Chinese Chemical Letters, ;1998, 9(12): 1087-1090. shu

Scavenging Effect of Perylenequinone Hydroxyls on Free Radicals:A Theoretical Study

Hong Yu ZHANG

Department of Biology, Provincial Key Laboratory of Animal ResistanceBiology, Shandong Teachers'University, Jinan 250014

Received Date: 21 June 1998

The semiempirical method AM1 was used to calculate △HOF values of perylenequinone (PQ), and △HOF was used as a theoretical parameter to predict the scavenging ability of PQ hydroxyls. Owing to strong intramolecular hydrogen bonds and the electron-attracting property of the keto-function, hydroxyls of PQ were so weak in scavenging free radicals that the its effect was negligible in photodynamic therapy. However, when PQ was substituted with strong electron-donating groups, its scavenging activity was enhanced markedly.
- Perylenequinonoid derivatives,
- antioxidant,
- AM1 method,
- △HOF value
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