Citation: Shu Li ZHAN, Chun Zhen ZHANG. STUDIES ON THE SYNTHESIS OF DIMETHYI,4-HYDROXY -4'-METHOXY-5,6,5',6'-BISMETHYLENEDIOXYBIPHENYL-2,2'-DICAPBOXYLATE——AN ESSENTIAL METABOLITE OF DDB[J]. Chinese Chemical Letters, ;1992, 3(1): 29-32. shu

STUDIES ON THE SYNTHESIS OF DIMETHYI,4-HYDROXY -4'-METHOXY-5,6,5',6'-BISMETHYLENEDIOXYBIPHENYL-2,2'-DICAPBOXYLATE——AN ESSENTIAL METABOLITE OF DDB

Institute of Materia Medica, Chinese Academy of Medical Sciences Beijing 100050

Received Date: 23 October 1991

This paper reports the total synthesis of dimethyl 4-hydroxy-4'-methoxy-5,6,5',6'-bismethylenedioxybiphenyl-2,2'-dicarboxylate (Ⅱ).Various conditions for bromination were tried to find the best one for synthesis of the key intermediate compd 6.After Lllmann condensation of 6 with 8 and hydrogenolysis,the title compd Ⅱ was obtained.It was proved to be identical with the isolated metabolite of DDB by spectral data.
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