Citation: Xiang Jun YUE, Ting Hao LI, Yu Lin LI. STUDIES ON THE STEREO-AND ENANTIOSELECTIVE SYNTHESIS OF 11．12-EPOXYSARCOPHYTOL-A, 11, 12-EPOXYSARCOPHYTOL-A ACETATE AND 11, 12-EPOXYCEMBRENE-C．-SYNTHESIS OF 5,9,13-TRIMETHYL-2-ISOPROPYL-12(S), 12(S)-EPOXY-141-BROMO-2(Z) ,4(E)- 8(E)-TETRADECATRIENENITRILE[J]. Chinese Chemical Letters, ;1995, 6(3): 189-192. shu

STUDIES ON THE STEREO-AND ENANTIOSELECTIVE SYNTHESIS OF 11．12-EPOXYSARCOPHYTOL-A, 11, 12-EPOXYSARCOPHYTOL-A ACETATE AND 11, 12-EPOXYCEMBRENE-C．-SYNTHESIS OF 5,9,13-TRIMETHYL-2-ISOPROPYL-12(S), 12(S)-EPOXY-141-BROMO-2(Z) ,4(E)- 8(E)-TETRADECATRIENENITRILE

a State Key Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000;
b Teaching and Research Section of Chemistry, Nanjing Forestry Universty, Nanjing 21

Received Date: 6 November 1994

Fund Project: This work was supported by the National Natural Science Foundation of China and by the Specia Research Grant for Doctoral Sites in Chinese Universities.

An efficient synthesis of 5,9,13-trimethyl-2-isopropyl-12(S),13(S)-epoxy-14-bromo-2(Z),4(E),8(E)-tetradecatrienenitrile,a key intermediate in the synthesis of antitumor cembranoids including 11,12-epoxy-sarcophytol-A,11,12-epoxysarcophytol-A acetate and 11,12-epoxycembrene-C,was first described through seven step sequence in～32% overall yield from E,E-farnesol.
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