Citation: De Qing LONG, De Jiang LI, Wei Quan CAI, Sheng Sheng CHEN. Synthesis and Fungicidal Activities of 2-Alkylthio-5-(3, 4, 5-tribenzyloxyphenyl)-1,3, 4-oxadiazoles[J]. Chinese Chemical Letters, ;2006, 17(11): 1427-1430. shu

Synthesis and Fungicidal Activities of 2-Alkylthio-5-(3, 4, 5-tribenzyloxyphenyl)-1,3, 4-oxadiazoles

1.
Department of Chemistry, Yunyang Teachers College, Hubei 442700;
2.
College of Chemical Engineering, Wuhan University of Technology, Wuhan 430070

Received Date: 8 September 2006

Fund Project: We gratefully acknowledge the financial support of the Natural Science Foundation of Education Department of Hubei Province (No. 2004D001).

Ten novel 2-alkylthio-5-(3, 4, 5-tribenzyloxyphenyl)-1, 3, 4-oxadiazole derivatives (5a-j) were synthesized from methyl 3, 4, 5-trihydroxybenzoate by etherification, hydrazidation, cyclization and thioetherification reactions. The structures of 5a-j were confirmed by ¹HNMR, MS spectra and elemental analysis. The results indicated that most of the compounds 5 exhibited good fungicidal activities. The activity of 5h is higher than 90% against Fusarium oxysporum and Botrytis cinereapers in 50 mg/L.
- 1,3,4-Oxadiazole derivatives,
- synthesis,
- fungicidal activity
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