Citation: Xue En JIA, Zhi Wei ZHANG, Liang TAN, You Yu ZHANG, Qing Ji XIE, Zhi Min HE, Shou Zhuo YAO. QCM Detection of Adhesion, Spreading and Proliferation of Human Breast Cancer Cells (MCF-7) on a Gold Surface[J]. Chinese Chemical Letters, ;2006, 17(4): 509-512. shu

QCM Detection of Adhesion, Spreading and Proliferation of Human Breast Cancer Cells (MCF-7) on a Gold Surface

1.
Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research(Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081;
2.
Cancer Research Institute, Xiangya Medical College, Central South University, Changsha 410078

Received Date: 8 September 2005

Fund Project: This work was supported by the National Natural Science Foundation of China (20275010, 20335020), the Basic Research Special Program of the Ministry of Science and Technology of China (2003CCC00700), and the Foundation of the Ministry of Education (MOE) of China (jiaorensi [2000] 26, jiaojisi [2000] 65).

The quartz crystal microbalance (QCM) was used to monitor the one-day incubation of human breast cancer cells (MCF-7) on the gold electrode. In combination with an optical microscope simulation experiment, the cell-population pictures at various stages, the QCM responses to the cells' adhesion, spreading and proliferation on the electrode surface were discussed. The △f₀ and △R₁responses were found mainly from mixed effects of viscodensity and surface stress, and in proportion to the cell coverage, rather than to the number of cells at the electrode. The significant fore-and-aft changes in cyclic voltammetry and electrochemical impedance spectroscopy of the ferri-ferrocyanide redox couple also proved that the cells were adhesion to the gold surface.
- Quartz crystal microbalance,
- optical microscopy,
- cyclic voltammetry,
- electrochemical impedance spectroscopy,
- human breast cancer cells (MCF-7)
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