Citation: Yang JIANG, Bo TAN, Yu Fen ZHAO. Theoretical Study of the Sensitivity-Improvement Effect of Phosphoryl Group in Mass Spectrometry of Small Peptides[J]. Chinese Chemical Letters, ;2001, 12(9): 807-808. shu

Theoretical Study of the Sensitivity-Improvement Effect of Phosphoryl Group in Mass Spectrometry of Small Peptides

The Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084

Received Date: 21 February 2001

Fund Project: The authors thank the National Natural Science Foundation of China (No. 39870415), the Ministry of Science and Technology of China, the Education Ministry of China and Tsinghua University for financial support.

It was found that phosphorylation of small peptide could improve the sensitivity in mass spectrometry. Density functional theory calculations showed that the energy for the protonation of N-(O, O'-dimethyl) phosphoryl glycylglycine is lower than that of glycylglycine. These could help to understanding the experimental results.
- Phosphoryl group,
- small peptide,
- mass spectrometry,
- relative energy
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