Citation: Xiang Qun LI, Zhen Wei MIAO, Yu LUO, Xiao Jie XU, You Qi TANG. Three Heptad Repeats Are Long Enough to Form Highly Stable α-Helix Structure[J]. Chinese Chemical Letters, ;1996, 7(9): 812-815. shu

Three Heptad Repeats Are Long Enough to Form Highly Stable α-Helix Structure

Department of Chemistry Peking University, Beijing 100871

Received Date: 5 March 1996

Fund Project: This work was supported by State Key Projects for Fundamental Research-Important Chemical Problems in Life Process.

As an attempt to find out how the sequence length determine the α-helix formation, seven peptides containing 2 to 4 heptad repeats (16-29 residues long) were designed and characterized. Results of circular dichroism (CD) show that two-heptad repeats are not long enough to form highly helical structure, while more than three are adequate, in aqueous solution.
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