Citation: Er Bao LIU, Hong Qing WEI, Xiu Li ZHAO, Xiao Xia LI, Feng Xian JIANG. Determination of Baicalin in Traditional Chinese Preparation by High Performance Liquid Chromatography with Chemiluminescence Detection[J]. Chinese Chemical Letters, ;2004, 15(9): 1067-1070. shu

Determination of Baicalin in Traditional Chinese Preparation by High Performance Liquid Chromatography with Chemiluminescence Detection

School of Chemistry and Material Science, Shanxi Normal University, Linfen 041004

Received Date: 29 July 2003

A new method for the determination of baicalin with HPLC-CL was developed. The method was based on the chemiluminescence reaction between KMnO₄ and baicalin sensitized from HCHO. The linear range was 3.7×10^-6~9.8×10^-5 mol/L with detection limit of 1.7×10^-6 mol/L and the relative standard deviation was 2.5% (Cs=6.6×10^-5 mol/L, n=5). The method has been applied to the determination of baicalin in oral administration, injection, Scutellariae radix and granules with good results.
- RP-HPLC,
- chemiluminescence analysis,
- baicalin
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