Citation: Gang LI, Qun Wei XU, Xiang Yin MO, Jia Ying CHEN, Guo Qiang SU. Study on Stability of Nateglinide Polymorphism[J]. Chinese Chemical Letters, ;2003, 14(7): 730-733. shu

Study on Stability of Nateglinide Polymorphism

1.
Chemistry and Physics Centralaboratry, Nanjing Normal University, Nanjing 210097;
2.
Jiangsu Institute of Materia Medica, Nanjing 210009

Received Date: 16 May 2002
Revised Date: 12 March 2003

Fund Project: The authors gratefully acknowledge the support of the Natural Science Foundation of Jiangsu Province (BK2001111), Jiangsu Province Key Lab of Drug Delivery System (DDS200101) and the Key Material Lab of Nanjing Normal University.

The stability of three forms of nateglinide, especially S-form and H-form, was determined. S-form was a new crystal structure1 of nateglinide. Three forms of nateglinide were treated in different conditions, such as in various temperatures, humidity, light and so on. Analysis of their crystal structures was performed by X-ray powder diffraction (XRD) and their particle shapes were observed with scanning electron microscope (SEM). The results indicated that the stability of S-form of nateglinide is the best among the three forms and their particle shapes are quite difference. S-form is the sheet structure of layer upon layer, H-form looks like a hank of silk lines and B-form is the clubbed shape.
- Diabetes,
- nateglinide,
- polymorphism,
- X-ray powder diffraction,
- stability
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