Citation: Suo De ZHANG, Gang LIU, Su Quan XIA, Ping WU. Design and Synthesis of Muramyl Dipeptide Cyclic Analogue[J]. Chinese Chemical Letters, ;2002, 13(1): 17-18. shu

Design and Synthesis of Muramyl Dipeptide Cyclic Analogue

1.
Beijing Institute of Pharmacology and Toxicology, Beijing 100850;
2.
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050

Received Date: 14 May 2001

A new conformationally restricted cyclic analogue of muramyl dipeptide was designed and manually synthesized by our "Meshed-Bag Gathered-Bunch" method with a combination of Fmoc, allyl and N-1-(4,4-dimethyl–2,6-dioxocyclo-hexylidene)ethyl chemical protection strategy.
- Muramyl dipeptide,
- "Meshed-Bag Gathered-Bunch" method,
- cyclic peptides,
- solidphase synthesis
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