Citation: ZHU Xi-Feng, GUO Yan-Chun, YU Zhi-Ran, LIAO Xin-Cheng, ZHAO Yu-Fen. Syntheses and Crystal Structures of Two New α-Aminophosphonate Derivatives Containing Thieno[2,3-d]pyrimidine[J]. Chinese Journal of Structural Chemistry, ;2015, 34(6): 879-884. doi: 10.14102/j.cnki.0254-5861.2011-0630 shu

Syntheses and Crystal Structures of Two New α-Aminophosphonate Derivatives Containing Thieno[2,3-d]pyrimidine

1.
a The College of Chemistry and Molecular Engineering, The Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, Zhengzhou University, Zhengzhou 450052, China;
2.
b Department of Chemistry, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen 361005, China

Corresponding author: GUO Yan-Chun,
Received Date: 12 January 2015
Available Online: 25 March 2015
Fund Project:

Two new α-aminophosphonate derivatives containing thieno[2,3-d]pyrimidine, diethyl(((6-ethyl-2-methyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)amino)(4-methoxyphenyl)methyl) phosphonate (1 and diethyl((4-bromophenyl)((6-ethyl-2-methyl-4-oxothieno[2,3-d]pyrimidin-3 (4H)-yl)amino)methyl)phosphonate (2), have been synthesized by a facial phosphorylated reaction, and their structures were characterized by NMR, IR, HRMS and X-ray single-crystal diffraction. Compound 1 (C₂₁H₂₈N₃O₅PS, M_r=465.49) belongs to the orthorhombic system, space group P2₁2₁2₁, with a=10.83653(16), b=12.04906(19), c=18.0061(3) Å, V=2351.06(6) Å³, Z=4, D_c=1.315 g/cm³, μ=2.177 mm^-1, F(000)=984.0, the final R=0.0389 and wR=0.0985 for all data. Compound 2 (C₂₀H₂₅BrN₃O₄PS, M_r=514.37) belongs to the orthorhombic system, space group P2₁2₁2₁, with a=10.9187(5), b=11.9522(4), c=17.7667(7) Å, V=2318.60(16) Å³, Z=4, D_c=1.474 g/cm³, μ=4.175 mm^-1, F(000)=1056.0, the final R=0.0367 and wR=0.0946 for all data.
- thieno[2,3-d]pyrimidine,
- α-aminophosphonate derivatives,
- synthesis,
- crystal structure
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