Citation: GUO Ying-Chen, MA Qin-Ge, CHEN Shu-Yang, FENG Yu-Quan, SUN Ru-Zhong. Syntheses, Crystal Structures and Anticancer Activities of Dithiocarbamate Bismuth(Ⅲ) Complexes[J]. Chinese Journal of Structural Chemistry, ;2015, 34(7): 1028-1034. doi: 10.14102/j.cnki.0254-5861.2011-0586 shu

Syntheses, Crystal Structures and Anticancer Activities of Dithiocarbamate Bismuth(Ⅲ) Complexes

1.
College of Chemistry and Pharmay Engineering, Nanyang Normal University, Nanyang 473061, China

Corresponding author: GUO Ying-Chen,
Received Date: 1 December 2014
Available Online: 1 June 2015
Fund Project: Supported by the International Cooperation Project of the Science & Technology Agency of Henan Province (No. 134300510013) (No. 134300510013)

Two novel complexes, [Bi(Ⅲ)(S₂CNBnEt)₃] 1 and [Bi(Ⅲ)(S₂CNPPPy-2)₃] 2, were synthesized and characterized by elemental analysis, IR, ¹H NMR, ¹³C NMR, TG-DTG and X-ray single-crystal diffraction. The structure reveals that complex 1 belongs to the monoclinic system, space group P2₁/c with a=11.457(5), b=17.437(8), c=33.439(14)Å, β=98.499(8)°, Z=4, V=6607(5)Å³, D_c=1.689 g·cm^-3, F(000)=3328, μ=5.742 mm^-1, the final R=0.0906, wR=0.1678 and S=1.032. The structure indicates that complex 2 belongs to the triclinic system, space group P1 with a=12.608(9), b=12.622(8), c=12.49(6)Å, α=102.652(15), β=103.013(14), γ=109.698(10)°, Z=1, V=1762.3(19)Å³, D_c=1.741 g·cm^-3, F(000)=916, μ=5.395 mm^-1, the final R=0.0482, wR=0.1206 and S=1.046. In the two complexes, each six-coordinated Bi(Ⅲ) atom adopts a pentagonal pyramidal configuration with six sulfur atoms from three ligands, and the dimmer structures are formed by weak interactions of Bi…S between two molecules. The anticancer activities of the two complexes were studied by evaluating their cytotoxicities against several human cancer cell lines using the MTT assay. Results indicated complex 2 showed moderate cytotoxic effects on the selected cancer cells.
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