Citation: LU Guang-Ying, FANG Jun. Synthesis, Antibacterial Activities and Theoretical Studies of Benzopyranocoumarin Derivatives[J]. Chinese Journal of Structural Chemistry, ;2016, 34(10): 1606-1611. doi: 10.14102/j.cnki.0254-5861.2011-0483 shu

Synthesis, Antibacterial Activities and Theoretical Studies of Benzopyranocoumarin Derivatives

LU Guang-Ying ^, ,
FANG Jun

1.
Boch Pharma. Technology (Shanghai) Co. Ltd, 201611, China

Corresponding author: LU Guang-Ying,
Received Date: 21 August 2014
Available Online: 24 August 2015

Three benzopyranocoumarins (OBH, OMH and ODH) were synthesized and characterized via IR, ¹H NMR and HRMS. The HB energy in OBH, OMH and ODH was performed with the density functional theory (DFT) [B3LYP/6-31G*] method. The in vitro antibacterial activity of OBH, OMH and ODH against drug-sensitive S. aureus (S. aureus ATCC 29213) strain, MRSA strain (MRSA XJ 75302), drug-sensitive S. epidermidis strain (S. epidermidis ATCC 14990) and methicillin-resistant S. epidermidis strain (MRSE XJ 75284) was evaluated by observing the minimum inhibitory concentration. The results showed that among the three compounds, ODH exhibited the most potent antibacterial activity.
- benzopyranocoumarin,
- density functional theory,
- Staphylococcus aureus,
- minimum inhibitory concentration
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