Citation: LIN Juan-Juan, MENG Fa-Yan, LI Xue-Hua. Synthesis, Crystal Structure and in vitro Anticancer Studies of 1,2-Bis-benzimidazole-phenyl Copper(Ⅱ) Complex[J]. Chinese Journal of Structural Chemistry, ;2015, 34(1): 41-48. doi: 10.14102/j.cnki.0254-5861.2011-0425 shu

Synthesis, Crystal Structure and in vitro Anticancer Studies of 1,2-Bis-benzimidazole-phenyl Copper(Ⅱ) Complex

1.
College of Pharmaceutical Sciences, Guangxi Medical University, Nanning 530021, China

Corresponding author: LI Xue-Hua,
Received Date: 19 June 2014
Available Online: 3 September 2014
Fund Project: This work was financially supported by the Natural Science Foundation of Guangxi Province (No. 2010GXNSF) (No. 2010GXNSF)Youth Science Foundation of Guangxi Medical University (No. 02604001015) (No. 02604001015)

One new benzimidazole derivative copper(Ⅱ) complex 1 (C₁₀H₆CuN₂, M_r=217.71) has been synthesized and characterized by FT-IR and X-ray single-crystal diffraction. It crystallizes in orthorhombic, space group Pbcn with a=17.417(2), b=8.9963(8), c=11.3432(9)Å, V=1777.3(3)Å³, Z=8, μ(MoKα)=2.403, F(000)=872, D_c=1.627 g/cm³. The final R=0.0598 for 1153 observed reflections with I>2σ(I) and wR=0.17 for all data. The in vitro anti-cancer activities of 1, CuCl₂ and the benzimidazole ligand L were investigated using human cervical (Hela) and hepatocellular carcinoma (Hep-G2) cancer cell lines. The copper(Ⅱ) complex can greatly inhibit the cell proliferation and show stronger cytotoxic activities against the tested cancer cell lines than both the ligand and copper(Ⅱ) salt.
- 1,2-bis-benzimidazole-phenyl,
- copper(Ⅱ),
- X-ray,
- anti-cancer,
- in vitro
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