Citation: Peng Liu. Cyclodextrins as versatile supramolecular building block in nanoscale drug delivery systems for precise tumor chemotherapy[J]. Chinese Chemical Letters, ;2025, 36(11): 111406. doi: 10.1016/j.cclet.2025.111406 shu

Cyclodextrins as versatile supramolecular building block in nanoscale drug delivery systems for precise tumor chemotherapy

Peng Liu

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China

pliu@lzu.edu.cn

Received Date: 23 March 2025
Revised Date: 20 May 2025
Accepted Date: 3 June 2025
Available Online: 3 June 2025

Figures(12)

Nanoscale drug delivery systems (nano-DDSs) have attracted intense interest in tumor chemotherapy in the last decades, to improve antitumor efficacy and minimize toxic and side effects. As a versatile supramolecular building block, cyclodextrins (CDs) have been widely used in the fabrication of the smart nano-DDSs. Besides their multifunctionality, which makes them versatile core in the star (co)polymers for micellar nanomedicines, specific host-guest inclusion complexation via their hydrophobic cavities endows them diversified functions: (ⅰ) design of amphiphilic copolymers for micellar nanomedicines, (ⅱ) supramolecular hydrogels and poly(pseudo)rotaxane nano-hydrogels as drug carriers, and (ⅲ) recipient for direct and indirect drug-loading. In the present work, the recent progress of CDs in nano-DDSs for tumor chemotherapy was reviewed, classified by the crucial roles of CD units. Based on the structure-performance relationship, the future perspective was also proposed.
- Nanoscale drug delivery system,
- Cyclodextrins,
- Supramolecular building block,
- Tumor chemotherapy,
- Structural design
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