Citation: Junxiu Zhao, Jingya Shi, Xiaoli Sun, Siyu Wang, Xuwei Han, Xiaoni Zhao, Jisheng Nie, Yongkang Yue. Heptamethine cyanine with 1239 nm fluorescence emission for in vivo imaging[J]. Chinese Chemical Letters, ;2026, 37(4): 111317. doi: 10.1016/j.cclet.2025.111317 shu

Heptamethine cyanine with 1239 nm fluorescence emission for in vivo imaging

Junxiu Zhao ^a ,
Jingya Shi ^a ,
Xiaoli Sun ^b ,
Siyu Wang ^a ,
Xuwei Han ^c ,
Xiaoni Zhao ^{c, *,} ,
Jisheng Nie ^{a, *,} ,
Yongkang Yue ^{c, *,}

a.
Key Laboratory of Coal Environmental Pathogenicity and Prevention, Ministry of Education, Shanxi Medical University, Taiyuan 030001, China
b.
Rushan Suboffice of Weihai Municipal Ecology and Environment Bureau, Rushan 264500, China
c.
Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China

zhaoxiaoni@sxu.edu.cn

niejisheng@sxmu.edu.cn

ykyue@sxu.edu.cn

Received Date: 26 February 2025
Revised Date: 28 April 2025
Accepted Date: 14 May 2025
Available Online: 15 May 2025

Figures(4)

Long-wavelength fluorescent dyes have revolutionized in vivo fluorescence imaging by offering unparalleled spatial resolution. Nevertheless, the majority of organic fluorescent dyes documented to date exhibit emission wavelengths predominantly within the range of 1000–1100 nm, with scarcely any surpassing the 1200 nm threshold. Herein, we introduce a heptamethine cyanine dye that boasts a remarkable fluorescence wavelength of 1239 nm. To our knowledge, this represents the longest fluorescence wavelength for heptamethine benzindole derivative. We have meticulously analyzed its photophysical characteristics and solvatochromic behavior, and assessed its efficacy in vivo fluorescence imaging applications.
- NIR-Ⅱ,
- Fluorescent dyes,
- Heptamethine cyanine,
- Cyanine limit,
- In vivo imaging
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