Citation: Meng Sun, Jiazhen Yang, Leijiao Li, Yunhui Li, Wenliang Li, Jianxun Ding. Engineered bacteria potentiate cancer immunotherapy[J]. Chinese Chemical Letters, ;2025, 36(9): 111093. doi: 10.1016/j.cclet.2025.111093 shu

Engineered bacteria potentiate cancer immunotherapy

Meng Sun ^{a, c} ,
Jiazhen Yang ^b ,
Leijiao Li ^a ,
Yunhui Li ^{a, c, *,} ,
Wenliang Li ^{a, *,} ,
Jianxun Ding ^{b, *,}

a.
School of Chemistry and Environmental Engineering, Changchun University of Science and Technology, Changchun 130022, China
b.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
c.
Zhongshan Institute of Changchun University of Science and Technology, Zhongshan 528400, China

liyh@cust.edu.cn

wenliangl@ciac.ac.cn

jxding@ciac.ac.cn

Received Date: 24 January 2025
Revised Date: 13 March 2025
Accepted Date: 14 March 2025
Available Online: 14 March 2025

Figures(4)

Immunotherapy offers the promise of a potential cure for cancer, yet achieving the desired therapeutic effect can be challenging due to the immunosuppressive tumor microenvironments (TMEs) present in some tumors. Therefore, robust immune system activation is crucial to enhance the efficacy of cancer immunotherapy in clinical applications. Bacteria have shown the ability to target the hypoxic TMEs while activating both innate and adaptive immune responses. Engineered bacteria, modified through chemical or biological methods, can be endowed with specific physiological properties, such as diverse surface antigens, metabolites, and improved biocompatibility. These unique characteristics give engineered bacteria distinct advantages in stimulating anti-cancer immune responses. This review explores the potential regulatory mechanisms of engineered bacteria in modulating both innate and adaptive immunity while also forecasting the future development and challenges of using engineered bacteria in clinical cancer immunotherapy.
- Engineered bacteria,
- Immunotherapy,
- Innate immune,
- Adaptive immune,
- Tumor immune reprogramming
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