Citation: Lingdan Kong, Pingping Huang, Feng Yuan, Yue Zhang, Xiaoqian Shi, Kang Han, Keke Liu, Qing Xu, Wenjing Zhang, Tom Lawson, Xiaoru Xia, Yong Liu, Yuepeng Jin. A metal-free bionic nanozyme for efficient inhibition of cancer recurrence and metastasis following photothermal therapy[J]. Chinese Chemical Letters, ;2025, 36(9): 111030. doi: 10.1016/j.cclet.2025.111030 shu

A metal-free bionic nanozyme for efficient inhibition of cancer recurrence and metastasis following photothermal therapy

Lingdan Kong ^{a, b, 1} ,
Pingping Huang ^{a, b, 1} ,
Feng Yuan ^{a, b, 1} ,
Yue Zhang ^{a, b} ,
Xiaoqian Shi ^{a, b} ,
Kang Han ^{a, b} ,
Keke Liu ^{a, b} ,
Qing Xu ^{a, b} ,
Wenjing Zhang ^{a, b} ,
Tom Lawson ^c ,
Xiaoru Xia ^{d, *,} ,
Yong Liu ^{a, b, *,} ,
Yuepeng Jin ^{e, *,}

a.
Laboratory of Novel Optoelectronic Technology for Ophthalmic Devices (NOTOD), School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, China
b.
National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China
c.
School of Chemical Engineering, University of New South Wales, Sydney NSW 2052, Australia
d.
Rheumatology Department, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325005, China
e.
National Key Clinical Specialty (General Surgery), the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325005, China

xxr7799@163.com

yongliu@wmu.edu.cn

quiet1981@163.com

Received Date: 17 December 2024
Revised Date: 26 February 2025
Accepted Date: 3 March 2025
Available Online: 3 March 2025

Figures(5)

Tumor heterogeneity and diversity significantly undermine the effectiveness of monotherapy. Collaborative therapy emerges as a promising approach to mitigate tumor recurrence resulting from monotherapy. Combining chemodynamic therapy (CDT) with photothermal therapy (PTT) offers a compelling solution for eradicating residual tumor cells post-PTT. In this study, we harness the Fenton-like response facilitated by glucose oxidase (GOD) and the mild hyperthermia induced by polyethyleneimine (PEI) functionalized nitrogen-containing graphene oxide to enhance tumor therapy through a metal-free bionic nanozyme. GOD catalyzes a substantial amount of hydrogen peroxide, and, with the carrier's involvement, triggers a Fenton-like reaction, yielding a wealth of hydroxyl radicals. These hydroxyl radicals effectively target tumor cells following photothermal action, bolstering CDT and culminating in a bidirectional amplification treatment that effectively prevents tumor recurrence and metastasis. This research amalgamates the physical and chemical attributes of nanomaterials with the unique characteristics of the tumor microenvironment, presenting a compelling and efficacious alternative for tumor treatment.
- Metal-free bionic nanozyme,
- Nitrogen-doped graphene,
- Chemodynamic therapy (CDT),
- Photothermal therapy (PTT),
- Tumor recurrence and metastasis
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