Citation: Lina Xie, Xiaohe Zhang, Xiaobo Wang, Zhen Zhang, Tianqi Nie, Jun Wu, Xiaojun Xu. Multifunctional GelMA hydrogel doped with spermidine-ferrocene polymeric nanoparticles for accelerative diabetic wound healing[J]. Chinese Chemical Letters, ;2025, 36(11): 110848. doi: 10.1016/j.cclet.2025.110848 shu

Multifunctional GelMA hydrogel doped with spermidine-ferrocene polymeric nanoparticles for accelerative diabetic wound healing

Lina Xie ^{a, 1} ,
Xiaohe Zhang ^{b, 1} ,
Xiaobo Wang ^{a, 1} ,
Zhen Zhang ^a ,
Tianqi Nie ^{c, *,} ,
Jun Wu ^{b, d, *,} ,
Xiaojun Xu ^{a, *,}

a.
Department of Hematology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China
b.
Bioscience and Biomedical Engineering Thrust, The Hong Kong University of Science and Technology (Guangzhou), Nansha, Guangzhou 511400, China
c.
Department of Otorhinolaryngology Head and Neck Surgery, Guangzhou Twelfth People's Hospital (The Affiliated Twelfth People's Hospital of Guangzhou Medical University), Guangzhou Medical University, Guangzhou 510620, China
d.
Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong 999077, China

nietq@mail2.sysu.edu.cn

junwuhkust@ust.hk

xuxj29@mail.sysu.edu.cn

Received Date: 18 December 2024
Revised Date: 9 January 2025
Accepted Date: 13 January 2025
Available Online: 13 January 2025

Figures(6)

Diabetic wounds are among the most challenging chronic wounds to heal, due to the presence of multiple factors, including continuous oxidative stress, impaired vascular integrity, and biofilm formation. The development of innovative treatment strategies is of paramount importance for the management of diabetic wounds. Stemmed from the pleiotropic physicochemical properties of ferrocene and spermidine, this essay reported the ferrocene-spermidine co-polymer (FcS) for the first time through facile amidation reaction. Molecular dynamics simulation revealed its self-assembly through hydrogen bonds, van der Waals forces instead of traditional nanoprecipitation. The self-assembled nanoparticles were demonstrated to exhibit great antioxidant property on cells to facilitate their migration and angiogenesis. Moreover, the integration with photocuring hydrogel, gelatin methacrylate (GelMA), to construct FcS nanoparticles loaded wound dressing (GelMA@FcS) further confirmed the potential on promoting diabetic wound enclosure through enhancement of re-epithelization and collagen deposition. Together with its great biocompatibility and biosafety, GelMA@FcS is expected to be developed into a wound dressing for clinical diabetic wounds management.
- Ferrocene,
- Spermidine,
- Hydrogel,
- Polymeric nanoparticles,
- Diabetic wound healing
1. [1]
  Y. Ding, Y.W. Zhou, P. Ling, et al., Theranostics 11 (2021) 9376–9396. doi: 10.7150/thno.64706
2. [2]
  X. Yang, B.J. Mathis, Y. Huang, W.C. Li, Y. Shi, J. Diabetes Res. 2021 (2021) 7945117.
3. [3]
  M. Wang, C.G. Wang, M. Chen, et al., ACS Nano 13 (2019) 10279–10293. doi: 10.1021/acsnano.9b03656
4. [4]
  O.A. Pena, P. Martin, Nat. Rev. Mol. Cell Biol. 25 (2024) 599–616. doi: 10.1038/s41580-024-00715-1
5. [5]
  X.L. Liang, C.L. Huang, H. Liu, et al., Chin. Chem. Lett. 35 (2024) 109442. doi: 10.1016/j.cclet.2023.109442
6. [6]
  Q.Z. Yang, D. Fang, J.X. Chen, et al., Theranostics 13 (2023) 3655–3674. doi: 10.7150/thno.85823
7. [7]
  K.K. Wu, M.M. Fu, Y.T. Zhao, et al., Bioact. Mater. 20 (2023) 93–110.
8. [8]
  H. Zhang, X. Lin, X.Y. Gao, et al., Bioact. Mater. 33 (2023) 355–376.
9. [9]
  X.Y. Wang, Y. Zhang, Y. Zhang, et al., Adv. Healthc. Mater. 13 (2024) 2303017. doi: 10.1002/adhm.202303017
10. [10]
  D. Bikle, S. Christakos, Nat. Rev. Endocrinol. 16 (2020) 234–252. doi: 10.1038/s41574-019-0312-5
11. [11]
  O. Yazarlu, M. Iranshahi, H.R.K. Kashani, et al., Pharmacol. Res. 174 (2021) 105841. doi: 10.1016/j.phrs.2021.105841
12. [12]
  M.H. Norahan, S.C. Pedroza-González, M.G. Sánchez-Salazar, M.M. Álvarez, G. Trujillo de Santiago, Bioact. Mater. 24 (2023) 197–235.
13. [13]
  T. Guan, J.Y. Li, C.Y. Chen, Y. Liu, Adv. Sci. 9 (2022) 2104165. doi: 10.1002/advs.202104165
14. [14]
  Y.F. Fang, G.Z. Li, C.L. Huang, et al., Int. J. Biol. Macromol. 229 (2023) 123–135. doi: 10.1016/j.ijbiomac.2022.12.046
15. [15]
  P.K. Xin, S.Y. Han, J. Huang, et al., Chin. Chem. Lett. 34 (2023) 108125. doi: 10.1016/j.cclet.2022.108125
16. [16]
  Y.F. Fang, T.Q. Nie, G.Z. Li, et al., Chem. Eng. J. 480 (2024) 147930. doi: 10.1016/j.cej.2023.147930
17. [17]
  G.T. Liu, Y. Zhou, Z.J. Xu, et al., Chin. Chem. Lett. 34 (2023) 107705. doi: 10.1016/j.cclet.2022.07.048
18. [18]
  Y.X. Wang, M.Y. Zhang, Z.Z. Yan, et al., Theranostics 14 (2024) 1534–1560. doi: 10.7150/thno.91829
19. [19]
  P. Mishra, J. Lee, D. Kumar, et al., Adv. Funct. Mater. 32 (2021) 2108650.
20. [20]
  F. Yang, G.Y. Guo, Y.B. Wang, Chem. Eng. J. 454 (2023) 140556. doi: 10.1016/j.cej.2022.140556
21. [21]
  M. Patra, G. Gasser, Nat. Rev. Chem. 1 (2017) 0066. doi: 10.1038/s41570-017-0066
22. [22]
  X. Liu, L. Zhao, F.F. Liu, D. Astruc, H.B. Gu, Coord. Chem. Rev. 419 (2020) 213406. doi: 10.1016/j.ccr.2020.213406
23. [23]
  X. Li, H.Y. Wang, Y.H. Zhang, Q.Y. Cao, Y. Chen, Chin. Chem. Lett. 32 (2021) 1541–1544. doi: 10.1016/j.cclet.2020.10.047
24. [24]
  J. Xu, J.J. Tan, C.Z. Song, et al., Angew. Chem. Int. Ed. 62 (2023) 202303829. doi: 10.1002/anie.202303829
25. [25]
  C.Z. Song, M.L. Chen, J.J. Tan, et al., J. Am. Chem. Soc. 145 (2023) 17755–17766. doi: 10.1021/jacs.3c04454
26. [26]
  Y.C. Gao, H.C. Zhang, L. Tang, et al., Adv. Sci. 11 (2024) 2300806. doi: 10.1002/advs.202300806
27. [27]
  Q.Q. Xu, X.M. Dai, L.L. Yang, et al., ACS Biomater. Sci. Eng. 8 (2022) 5018–5026. doi: 10.1021/acsbiomaterials.2c00986
28. [28]
  Y. Zhang, J. Bai, Z.K. Cui, et al., Nat. Aging 3 (2023) 1372–1386. doi: 10.1038/s43587-023-00498-8
29. [29]
  F. Madeo, T. Eisenberg, F. Pietrocola, G. Kroemer, Science 359 (2018) 2788. doi: 10.1126/science.aan2788
30. [30]
  S.J. Hofer, A.K. Simon, M. Bergmann, et al., Nat. Aging 2 (2022) 1112–1129. doi: 10.1038/s43587-022-00322-9
31. [31]
  Q.Q. Wu, R.J. Yang, W.X. Fan, et al., Adv. Sci. 11 (2024) 2310162. doi: 10.1002/advs.202310162
32. [32]
  L. Wang, Y.H. Zhong, Q.Q. Wu, et al., Chem. Eng. J. 476 (2023) 146416. doi: 10.1016/j.cej.2023.146416
1. [1]
  Yue Sun , Yingnan Zhu , Jiahang Si , Ruikang Zhang , Yalan Ji , Jinjie Fan , Yuze Dong . Glucose-activated nanozyme hydrogels for microenvironment modulation via cascade reaction in diabetic wound. Chinese Chemical Letters, 2025, 36(4): 110012-. doi: 10.1016/j.cclet.2024.110012
2. [2]
  Jiajia Wang , XinXin Ge , Yajing Xiang , Xiaoliang Qi , Ying Li , Hangbin Xu , Erya Cai , Chaofan Zhang , Yulong Lan , Xiaojing Chen , Yizuo Shi , Zhangping Li , Jianliang Shen . An ionic liquid functionalized sericin hydrogel for drug-resistant bacteria-infected diabetic wound healing. Chinese Chemical Letters, 2025, 36(2): 109819-. doi: 10.1016/j.cclet.2024.109819
3. [3]
  Peizhe Li , Qiaoling Liu , Mengyu Pei , Yuci Gan , Yan Gong , Chuchen Gong , Pei Wang , Mingsong Wang , Xiansong Wang , Da-Peng Yang , Bo Liang , Guangyu Ji . Chlorogenic acid supported strontium polyphenol networks ensemble microneedle patch to promote diabetic wound healing. Chinese Chemical Letters, 2024, 35(8): 109457-. doi: 10.1016/j.cclet.2023.109457
4. [4]
  Qiang Fang , Yingbo Lu , Jianying Huang , Cheng Zhang , Jing Wu , Shijun Li . An electrochemical immunosensor based on an antibody-ferrocene-functionalized covalent organic framework. Chinese Chemical Letters, 2026, 37(2): 111218-. doi: 10.1016/j.cclet.2025.111218
5. [5]
  Tingting Hu , Chao Shen , Xueyan Wang , Fengbo Wu , Zhiyao He . Tumor microenvironment-sensitive polymeric nanoparticles for synergetic chemo-photo therapy. Chinese Chemical Letters, 2024, 35(11): 109562-. doi: 10.1016/j.cclet.2024.109562
6. [6]
  Hong Wang , Yong Tian , Tiancheng Wu , Shun He , Jiaxi Cui , Jian Chen , Xudong Chen . Photoswitchable dual-color fluorescent polymeric nanoparticles for self-erased time-resolved information encryption and anti-counterfeiting. Chinese Chemical Letters, 2025, 36(7): 110509-. doi: 10.1016/j.cclet.2024.110509
7. [7]
  Mengchen Liu , Yufei Zhang , Yi Xiao , Yang Wei , Meichen Bi , Huaide Jiang , Yan Yu , Shenghong Zhong . High stretchability and toughness of liquid metal reinforced conductive biocompatible hydrogels for flexible strain sensors. Chinese Journal of Structural Chemistry, 2025, 44(3): 100518-100518. doi: 10.1016/j.cjsc.2025.100518
8. [8]
  Ruijun Song , Huixu Xie , Guiting Liu . Advances of MXene-based hydrogels for chronic wound healing. Chinese Chemical Letters, 2025, 36(7): 110442-. doi: 10.1016/j.cclet.2024.110442
9. [9]
  Aijia Zhang , Guiyuan Zhao , Guangli Xiang , Rui Chen , Yu Dong , Qijie Diao , Jialin Wang , Xiaohui Lin , Wenxuan Zeng , Tianze Jiang , Jun Wu , Xia Zhao . Barnacle-inspired chitosan glycerin gel for skin protection and wound healing in harsh environments. Chinese Chemical Letters, 2025, 36(8): 110767-. doi: 10.1016/j.cclet.2024.110767
10. [10]
  Yang Xu , Le Ma , Yang Wang , Chunmeng Shi . Engineering strategies of biomaterial-assisted exosomes for skin wound repair: Latest advances and challenges. Chinese Chemical Letters, 2025, 36(1): 109766-. doi: 10.1016/j.cclet.2024.109766
11. [11]
  Xi Chen , Xue Zhang , Shuai Yang , Jie Wang , Tian Tang , Maling Gou . An adhesive hydrogel for the treatment of oral ulcers. Chinese Chemical Letters, 2025, 36(3): 110021-. doi: 10.1016/j.cclet.2024.110021
12. [12]
  Zhuan Chen , Bo Yang , Jun Li , Kun Du , Jiangchen Fu , Xiao Wu , Jiazhen Cao , Mingyang Xing . Environmentally safe storage and sustained release of hydrogen peroxide utilizing commercial hydrogel. Chinese Chemical Letters, 2025, 36(6): 110320-. doi: 10.1016/j.cclet.2024.110320
13. [13]
  Zeyang Yao , Xinru You , Xudong Wang , Yunze Kang , Liying Wang , Ziji Zhang . Stem cell-based hydrogel for the repair and regeneration of cartilage. Chinese Chemical Letters, 2025, 36(8): 110607-. doi: 10.1016/j.cclet.2024.110607
14. [14]
  Yingqiang Liang , Shilun Li , Yixiao Pan , Weiyu Zhang , Shupeng Liu , Yiwen Chen , Jiangfeng Hu , Xueliang Zhang , Jun Zhao , Zhigang Zheng . Exosome-hybridized hydrogel acts as a foamy protective coat for the liver. Chinese Chemical Letters, 2025, 36(11): 110841-. doi: 10.1016/j.cclet.2025.110841
15. [15]
  Yongzhi Wu , Rong He , Bowen Tan , Longjiang Li , Jinfeng Liao . An injectable hydrogel for chemodynamic therapy-induced ferroptosis in malignant melanoma. Chinese Chemical Letters, 2026, 37(3): 111339-. doi: 10.1016/j.cclet.2025.111339
16. [16]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225
17. [17]
  Tong Zhang , Xiaojing Liang , Licheng Wang , Shuai Wang , Xiaoxiao Liu , Yong Guo . An ionic liquid assisted hydrogel functionalized silica stationary phase for mixed-mode liquid chromatography. Chinese Chemical Letters, 2025, 36(1): 109889-. doi: 10.1016/j.cclet.2024.109889
18. [18]
  Xiaoyu Hou , Mingyang Liu , Hu Wu , Nan Wang , Xu Zhao , Xifeng Qin , Xiaomin Su , Hanwei Huang , Zihan Ma , Jiahao Liu , Onder Ergonul , Füsun Can , Wei Liu , Zhiqing Pang , Funan Liu . Differential releasing hydrogel loaded with oncolytic viruses and anti-CAFs drug to enhance oncology therapeutic efficacy. Chinese Chemical Letters, 2025, 36(5): 110106-. doi: 10.1016/j.cclet.2024.110106
19. [19]
  Xicheng Li , Dong Mo , Shoushan Hu , Meng Pan , Meng Wang , Tingyu Yang , Changxing Qu , Yujia Wei , Jianan Li , Hanzhi Deng , Zhongwu Bei , Tianying Luo , Qingya Liu , Yun Yang , Jun Liu , Jun Wang , Zhiyong Qian . A Pt@ZIF-8/ALN-ac/GelMA composite hydrogel with antibacterial, antioxidant, and osteogenesis for periodontitis. Chinese Chemical Letters, 2025, 36(9): 110674-. doi: 10.1016/j.cclet.2024.110674
20. [20]
  Weiqi Zhang , Hang Wu , Limin Xie , Yixin Liang , Xiaowan Huang , Zhimou Yang , Tengyan Xu , Feng Lin . A two-component peptide-based hydrogel for endometrial repair and restoring fertility. Chinese Chemical Letters, 2025, 36(10): 110800-. doi: 10.1016/j.cclet.2024.110800

Get Citation

PDF

XML

Metrics

PDF Downloads(2)
Abstract views(753)
HTML views(19)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142