Citation: Yaojun Li, Yun Li, Shenglong Liao, Yang Li, Shouchun Yin. Revolutionizing cancer therapies with organic photovoltaic non-fullerene acceptors: A deep dive into molecular engineering for advanced phototheranostics[J]. Chinese Chemical Letters, ;2025, 36(8): 110832. doi: 10.1016/j.cclet.2025.110832 shu

Revolutionizing cancer therapies with organic photovoltaic non-fullerene acceptors: A deep dive into molecular engineering for advanced phototheranostics

Yaojun Li ^a ,
Yun Li ^a ,
Shenglong Liao ^b ,
Yang Li ^a ,
Shouchun Yin ^{a, *,}

a.
Key Laboratory of Organosilicon Chemistry and Materials Technology of Ministry of Education, College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China
b.
School of Engineering, Hangzhou Normal University, Hangzhou 311121, China

yinsc@hznu.edu.cn

Received Date: 15 October 2024
Revised Date: 19 December 2024
Accepted Date: 6 January 2025
Available Online: 10 January 2025

Figures(27)

The integration of advanced diagnostic and therapeutic capabilities in oncology has given rise to phototheranostics, a field that combines the precision of imaging with the selectivity of light-activated treatments. Due to their pronounced near-infrared (NIR) absorption, tunable molecular structures, and commendable stability, organic photovoltaic non-fullerene acceptors (NFAs) represent a promising frontier in cancer management. Despite the great potential of NFAs in phototheranostics, there is currently a lack of systematic reviews in this field. This review provides a meticulous examination of the current state of NFAs in the field of phototheranostics, highlighting the strategic approaches to spectral red-shifting that enhance tissue penetration and therapeutic efficacy. It dissects the link between molecular architecture and performance across key therapeutic and diagnostic modalities, including photothermal therapy (PTT), photodynamic therapy (PDT), and fluorescence imaging (FLI). In addition, the review presents a concise analysis of the challenges and milestones in the clinical translation of NFAs, offering insights into the innovations required to overcome existing barriers.
- Phototheranostics,
- Non-fullerene acceptors,
- Photothermal therapy,
- Photodynamic therapy,
- Fluorescence imaging
1. [1]
  R.L. Siegel, K.D. Miller, N.S. Wagle, A. Jemal, CA Cancer J. Clin. 73 (2023) 17–48. doi: 10.3322/caac.21763
2. [2]
  R.L. Siegel, A.N. Giaquinto, A. Jemal, CA Cancer J. Clin. 74 (2024) 12–49. doi: 10.3322/caac.21820
3. [3]
  H. Stower, Nat. Med. 26 (2020) 1804–1805. doi: 10.1038/s41591-020-01151-2
4. [4]
  M. Ghasemlou, N. Pn, K. Alexander, et al., Adv. Mater. 36 (2024) e2312474.
5. [5]
  A. Pulumati, A. Pulumati, B.S. Dwarakanath, Cancer Rep. 6 (2023) e1764.
6. [6]
  J.S.J. Britto, X. Guan, T.K.A. Tran, et al., Small Sci. 4 (2024) 2300221.
7. [7]
  Y. Dai, H. Zhao, K. He, et al., Small 17 (2021) e2102527.
8. [8]
  L. Wang, N. Li, W. Wang, et al., ACS Nano 18 (2024) 4683–4703. doi: 10.1021/acsnano.3c12316
9. [9]
  S. Wang, W.X. Ren, J.T. Hou, et al., Chem. Soc. Rev. 50 (2021) 8887–8902. doi: 10.1039/d1cs00083g
10. [10]
  B. Nasseri, E. Alizadeh, F. Bani, et al., Appl. Phys. Rev. 9 (2022) 011317–011320.
11. [11]
  V.N. Nguyen, Z. Zhao, B.Z. Tang, J. Yoon, Chem. Soc. Rev. 51 (2022) 3324–3340. doi: 10.1039/d1cs00647a
12. [12]
  V.V. Brus, J. Lee, B.R. Luginbuhl, et al., Adv. Mater. 31 (2019) e1900904.
13. [13]
  J. Wang, P. Xue, Y. Jiang, Y. Huo, X. Zhan, Nat. Rev. Chem. 6 (2022) 614–634.
14. [14]
  C. Zhu, J. Yuan, F. Cai, et al., Energy Environ. 13 (2020) 2459–2466. doi: 10.1039/d0ee00862a
15. [15]
  Y. Cui, H. Yao, J. Zhang, et al., Adv. Mater. 32 (2020) e1908205.
16. [16]
  A. Armin, W. Li, O.J. Sandberg, et al., Adv. Energy Mater. 11 (2021) 20003570.
17. [17]
  Y. Cai, Z. Wei, C. Song, et al., Chem. Commun. 55 (2019) 8967–8970. doi: 10.1039/c9cc04195h
18. [18]
  G. Zhang, W. Wang, H. Zou, et al., J. Mater. Chem. B 9 (2021) 5318–5328. doi: 10.1039/d1tb00659b
19. [19]
  C. Li, G. Jiang, J. Yu, et al., Adv. Mater. 35 (2023) e2208229.
20. [20]
  Q. Wang, J. Xu, R. Geng, et al., Biomaterials 231 (2020) 119671.
21. [21]
  H. Chen, S. Yan, L. Zhang, et al., Sensors Actuators B: Chem. 405 (2024) 135346.
22. [22]
  J. Xia, H. Quan, Y. Huang, et al., ACS Macro Lett. 13 (2024) 489–494. doi: 10.1021/acsmacrolett.4c00031
23. [23]
  K. Yang, Z. Zhang, Y. Gan, et al., J. Mater. Chem. B 10 (2022) 7622–7627. doi: 10.1039/d2tb00984f
24. [24]
  Y. Yuan, Z. Feng, S. Li, et al., Adv. Mater. 34 (2022) e2201263.
25. [25]
  W. Fan, Y. He, P. Hu, et al., J. Colloid Interface Sci. 670 (2024) 762–773.
26. [26]
  D. Li, Y. Li, Q. Wu, et al., Small 17 (2021) e2102044.
27. [27]
  X. Li, F. Fang, B. Sun, et al., Nanoscale Horiz. 6 (2021) 177–185. doi: 10.1039/d0nh00672f
28. [28]
  H. Yuan, Z. Li, Q. Zhao, et al., Adv. Funct. Mater. 33 (2023) 2213209.
29. [29]
  X. Li, L. Liu, S. Li, et al., ACS Nano 13 (2019) 12901–12911. doi: 10.1021/acsnano.9b05383
30. [30]
  B. Lu, H. Quan, Z. Zhang, et al., Nano Lett. 23 (2023) 2831–2838. doi: 10.1021/acs.nanolett.3c00119
31. [31]
  B. Lu, Y. Huang, H. Quan, et al., ACS Macro Lett. 12 (2023) 1365–1371. doi: 10.1021/acsmacrolett.3c00454
32. [32]
  B. Lu, J. Xia, H. Quan, et al., Small 20 (2023) e2307664.
33. [33]
  L. Li, C. Shao, T. Liu, et al., Adv. Mater. 32 (2020) e2003471.
34. [34]
  B. Lu, Z. Zhang, Y. Ji, et al., Sci. China Chem. 65 (2022) 1134–1141. doi: 10.1007/s11426-022-1232-9
35. [35]
  B. Lu, Z. Zhang, Y. Huang, et al., Chem. Commun. 58 (2022) 10353–10356. doi: 10.1039/d2cc03248a
36. [36]
  B. Li, Y. Gan, K. Yang, et al., Sci. Chin. Mater. 66 (2022) 385–394.
37. [37]
  Z. He, L. Zhao, Q. Zhang, et al., Adv. Funct. Mater. 30 (2020) 1910301.
38. [38]
  X.F. Zhu, C.C. Liu, Z.B. Hu, et al., Nano Res. 13 (2020) 2570–2575. doi: 10.1007/s12274-020-2901-y
39. [39]
  Y. Zhu, H. Lai, Y. Gu, et al., Adv. Sci. 11 (2024) e2307569.
40. [40]
  B. Lu, Z. Zhang, D. Jin, et al., Chem. Commun. 57 (2021) 12020–12023. doi: 10.1039/d1cc04629b
41. [41]
  Y. Cai, C. Tang, Z. Wei, et al., ACS Appl. Bio Mater. 4 (2021) 1942–1949. doi: 10.1021/acsabm.0c01576
42. [42]
  M. Li, Z. Lu, J. Zhang, et al., Adv. Mater. 35 (2023) e2209647.
43. [43]
  C. Song, J. Ran, Z. Wei, et al., ACS Appl. Mater. Interfaces 13 (2021) 3547–3558. doi: 10.1021/acsami.0c18841
44. [44]
  H. Xiao, Y. Wang, J. Chen, et al., Adv. Healthc. Mater. 13 (2024) e2303183.
45. [45]
  Y. Zhu, H. Lai, H. Guo, et al., Angew. Chem. Int. Ed. 61 (2022) e202117433.
46. [46]
  Z. Liu, J. Wen, G. Zhou, et al., Adv. Ther. 5 (2022) 2200168.
47. [47]
  S. Jia, Z. Li, J. Shao, et al., ACS Appl. Polym. Mater. 4 (2022) 5275. doi: 10.1021/acsapm.2c00699
48. [48]
  Y. Zhao, Y. Cui, S. Xie, et al., Biomater. Sci. 12 (2024) 4386–4392. doi: 10.1039/d4bm00605d
49. [49]
  K. Yang, B. Yu, W. Liu, et al., Chin. Chem. Lett. 34 (2023) 107889–107894.
50. [50]
  Y.J. Li, J.T. Ye, Y. Li, et al., Polym. Chem. 14 (2023) 3008–3017. doi: 10.1039/d3py00461a
51. [51]
  Y. Gu, H. Lai, Z.Y. Chen, et al., Angew. Chem. Int. Ed. 62 (2023) e202303476.
52. [52]
  K. Yang, F. Long, W. Liu, et al., ACS Appl. Mater. Interfaces 14 (2022) 18043–18052. doi: 10.1021/acsami.1c22444
53. [53]
  B. Yin, Q. Qin, Z. Li, et al., Nano Today 45 (2022) 101550.
54. [54]
  G. Niu, X. Bi, Y. Kang, et al., Adv. Mater. 36 (2024) 2407199.
55. [55]
  C. Xu, K. Pu, Chem. Soc. Rev. 50 (2021) 1111–1137. doi: 10.1039/d0cs00664e
56. [56]
  Y. Lu, M. Li, Adv. Funct. Mater. 34 (2024) 2312753.
57. [57]
  Y. Li, M. Jiang, M. Yan, et al., Coord. Chem. Rev. 506 (2024) 215718–215737.
58. [58]
  P. Cheng, Y. Yang, Acc. Chem. Res. 53 (2020) 1218–1228. doi: 10.1021/acs.accounts.0c00157
59. [59]
  D. Meng, R. Zheng, Y. Zhao, et al., Adv. Mater. 34 (2022) e2107330.
60. [60]
  X. Wan, C. Li, M. Zhang, Y. Chen, Chem. Soc. Rev. 49 (2020) 2828–2842. doi: 10.1039/d0cs00084a
61. [61]
  Y. Che, M.R. Niazi, R. Izquierdo, D.F. Perepichka, Angew. Chem. Int. Ed. 60 (2021) 24833–24837. doi: 10.1002/anie.202109357
62. [62]
  Y. Lin, J. Wang, Z.G. Zhang, et al., Adv. Mater. 27 (2015) 1170–1174. doi: 10.1002/adma.201404317
63. [63]
  X.D. Zhang, H. Wang, A.L. Antaris, et al., Adv. Mater. 28 (2016) 6872–6879. doi: 10.1002/adma.201600706
64. [64]
  Y. Su, B. Yu, S. Wang, H. Cong, Y. Shen, Biomaterials 271 (2021) 120717.
65. [65]
  Y. Maruoka, T. Nagaya, K. Sato, et al., Mol. Pharm. 15 (2018) 3634–3641. doi: 10.1021/acs.molpharmaceut.8b00002
66. [66]
  X. Yin, Y. Cheng, Y. Feng, et al., Adv. Drug Del. Rev. 189 (2022) 114483.
67. [67]
  J. Ma, X. Yang, Y. Sun, J. Yang, Sci. Rep. 9 (2019) 10987.
68. [68]
  Y.Y. Zhao, H. Kim, V.N. Nguyen, et al., Coord. Chem. Rev. 501 (2024) 215560–215573.
69. [69]
  S. Liu, X. Zhou, H. Zhang, et al., J. Am. Chem. Soc. 141 (2019) 5359–5368. doi: 10.1021/jacs.8b13889
70. [70]
  Z. Zhao, C. Chen, W. Wu, et al., Nat. Commun. 10 (2019) 768–778.
71. [71]
  X.W. Liu, W. Zhao, Y. Wu, et al., Nat. Commun. 13 (2022) 3887–3894.
72. [72]
  S. Sasaki, G.P.C. Drummen, G.I. Konishi, J. Mater. Chem. C 4 (2016) 2731–2743.
73. [73]
  Q. Yang, Z. Hu, S. Zhu, et al., J. Am. Chem. Soc. 140 (2018) 1715–1724. doi: 10.1021/jacs.7b10334
74. [74]
  D. Liese, G. Haberhauer, Isr. J. Chem. 58 (2018) 813–826. doi: 10.1002/ijch.201800032
75. [75]
  Z.Z. Zou, H.C. Chang, H.L. Li, S.M. Wang, Apoptosis 22 (2017) 1321–1335. doi: 10.1007/s10495-017-1424-9
76. [76]
  E. Pang, S.J. Zhao, B.H. Wang, et al., Coord. Chem. Rev. 472 (2022) 214780–214795.
77. [77]
  Y. Cai, W. Si, W. Huang, P. Chen, J. Shao, et al., Small 14 (2018) e1704247.
78. [78]
  X. Li, N. Kwon, T. Guo, Z. Liu, J. Yoon, Angew. Chem. Int. Ed. 57 (2018) 11522–11531. doi: 10.1002/anie.201805138
79. [79]
  S. Liu, H. Zhang, Y. Li, et al., Angew. Chem. Int. Ed. 57 (2018) 15189–15193. doi: 10.1002/anie.201810326
80. [80]
  X. Wang, Y. Song, G. Pan, et al., Chem. Sci. 11 (2020) 10921–10927. doi: 10.1039/d0sc03128c
81. [81]
  L. Huang, D. Qing, S. Zhao, et al., Chem. Eng. J. 430 (2022) 132638–132642.
82. [82]
  Y. Yu, S. Wu, L. Zhang, et al., Biomaterials 280 (2022) 121255.
83. [83]
  Z. Zhuang, J. Li, P. Shen, Z. Zhao, B.Z. Tang, Aggregate 5 (2024) e540.
84. [84]
  A. Huang, L. Su, Acc. Mater. Res. 4 (2023) 729–732. doi: 10.1021/accountsmr.3c00098
85. [85]
  Z. Zhao, S. Lei, M. Zeng, M. Huo, Aggregate 5 (2023) e418.
86. [86]
  S.A. Chen, T.H. Jen, H.H. Lu, J. Chin. Chem. Soc. 57 (2013) 439–458. doi: 10.1007/978-1-4614-3320-0_27
87. [87]
  P. Shen, H. Liu, Z. Zhuang, et al., Adv. Sci. 9 (2022) 2200374.
88. [88]
  Y. Tian, D. Yin, L. Yan, WIREs Nanomed. Nanobiotechnol. 15 (2023) e1831.
89. [89]
  G. Han, T. Hu, Y. Yi, Adv. Mater. 32 (2020) 2000975.
90. [90]
  S. Song, Y. Zhao, M. Kang, et al., Adv. Funct. Mater. 31 (2021) 2107545.
91. [91]
  Y. Jin, Q.C. Peng, S. Li, et al., Natl. Sci. Rev. 9 (2022) nwab216.
92. [92]
  J. Xia, S. Xie, Y. Huang, X.X. Wu, B. Lu, Chem. Commun. 60 (2024) 8526– 8536. doi: 10.1039/d4cc02596b
93. [93]
  Y. Wan, L.H. Fu, C. Li, J. Lin, P. Huang, Adv. Mater. 33 (2021) e2103978.
94. [94]
  L. Huang, S. Zhao, J. Wu, et al., Coord. Chem. Rev. 438 (2021) 213888–213908.
95. [95]
  B. Lu, L. Wang, H. Tang, D. Cao, J. Mater. Chem. B 11 (2023) 4600–4618. doi: 10.1039/d3tb00545c
96. [96]
  K.X. Teng, W.K. Chen, L.Y. Niu, et al., Angew. Chem. Int. Ed. 60 (2021) 19912–19920. doi: 10.1002/anie.202106748
97. [97]
  K.X. Teng, L.Y. Niu, Q.Z. Yang, J. Am. Chem. Soc. 145 (2023) 4081–4087. doi: 10.1021/jacs.2c11868
98. [98]
  X. Hu, Z. Fang, F. Sun, et al., Angew. Chem. Int. Ed. 63 (2024) e202401036.
99. [99]
  Z. Hu, C. Fang, B. Li, et al., Nat. Biomed. Eng. 4 (2020) 259–271.
100. [100]
  Q. Ma, X. Sun, W. Wang, et al., Chin. Chem. Lett. 33 (2022) 1681–1692.
101. [101]
  W. Zhang, X. Du, Y. Ma, et al., Adv. Funct. Mater. 34 (2023) 2308591.
102. [102]
  Z. Wang, M. Zhang, S. Chi, et al., Adv. Healthc. Mater. 11 (2022) e2200521.
103. [103]
  F. Zhao, X. Zhang, F. Bai, et al., Adv. Mater. 35 (2023) e2208097.
104. [104]
  H. Ren, J. Li, J.F. Lovell, Y. Zhang, Coord. Chem. Rev. 503 (2024) 215634–215653.
105. [105]
  Y. Dai, Z. Sun, H. Zhao, et al., Biomaterials 275 (2021) 120935.
106. [106]
  S. Song, Y. Zhao, M. Kang, et al., Adv. Mater. 36 (2024) e2309748.
107. [107]
  N. Liang, D. Meng, Z. Wang, Acc. Chem. Res. 54 (2021) 961–975. doi: 10.1021/acs.accounts.0c00677
108. [108]
  X. Zhao, F. Zhang, Z. Lei, Chem. Sci. 13 (2022) 11280–11293. doi: 10.1039/d2sc03136a
109. [109]
  H. Li, Q. Li, Y. Gu, et al., Aggregate 5 (2024) e528.
110. [110]
  S. Yang, G.L. Wu, N. Li, et al., J. Nanobiotechnol. 20 (2022) 475.
111. [111]
  S. Yang, B. Sun, F. Liu, et al., Small 19 (2023) e2207995.
112. [112]
  J. Ye, Y. Yu, Y. Li, et al., ACS Appl. Mater. Interfaces 16 (2024) 34607–34619. doi: 10.1021/acsami.4c05334
113. [113]
  P. Hu, X. Peng, S. Zhao, et al., Chem. Eng. J. 492 (2024) 152033.
114. [114]
  W. Li, T. Ma, T. He, Y. Li, S. Yin, Chem. Eng. J. 463 (2023) 142495.
115. [115]
  T. Ma, W. Li, J. Ye, et al., Nanoscale 15 (2023) 16947–16958. doi: 10.1039/d3nr03881e
116. [116]
  K. Yang, S. Zhao, B. Li, et al., Coord. Chem. Rev. 454 (2022) 214330.
117. [117]
  Z. Chen, S. Li, F. Li, et al., Adv. Sci. 10 (2023) e2206707.
118. [118]
  X. He, S. Zhang, Y. Tian, W. Cheng, H. Jing, Int. J. Nanomed. 18 (2023) 1433–1468. doi: 10.2147/ijn.s405020
119. [119]
  W. Wang, J. Yu, Y. Lin, et al., Biomater. Adv. 149 (2023) 213418.
120. [120]
  B. Li, G. Fu, C. Liu, et al., J. Colloid Interface Sci. 665 (2024) 389–398.
121. [121]
  J. Li, K. Kataoka, J. Am. Chem. Soc. 143 (2021) 538–559. doi: 10.1021/jacs.0c09029
122. [122]
  P. Wen, W. Ke, A. Dirisala, et al., Adv. Drug Deliv. Rev. 198 (2023) 114895.
123. [123]
  C. He, P. Feng, M. Hao, et al., Adv. Funct. Mater. 34 (2024) 2402588.
1. [1]
  Du Liu , Yuyan Li , Hankun Zhang , Benhua Wang , Chaoyi Yao , Minhuan Lan , Zhanhong Yang , Xiangzhi Song . Three-in-one erlotinib-modified NIR photosensitizer for fluorescence imaging and synergistic chemo-photodynamic therapy. Chinese Chemical Letters, 2025, 36(2): 109910-. doi: 10.1016/j.cclet.2024.109910
2. [2]
  Leichen Wang , Anqing Mei , Na Li , Xiaohong Ruan , Xu Sun , Yu Cai , Jinjun Shao , Xiaochen Dong . Aza-BODIPY dye with unexpected bromination and high singlet oxygen quantum yield for photoacoustic imaging-guided synergetic photodynamic/photothermal therapy. Chinese Chemical Letters, 2024, 35(6): 108974-. doi: 10.1016/j.cclet.2023.108974
3. [3]
  Xuejian Xing , Pan Zhu , E Pang , Shaojing Zhao , Yu Tang , Zheyu Hu , Quchang Ouyang , Minhuan Lan . D-A-D-structured boron-dipyrromethene with aggregation-induced enhanced phototherapeutic efficiency for near-infrared fluorescent and photoacoustic imaging-guided synergistic photodynamic and photothermal cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109452-. doi: 10.1016/j.cclet.2023.109452
4. [4]
  Xu Sun , Mengchen Luo , Xinyu Xie , Mengyao Liu , Weili Wang , Tian Zhang , Lei An , Jinjun Shao , Xiaochen Dong , Yu Cai . Thienothiadiazole-based NIR-Ⅱ D-A-D dye for fluorescence and photoacoustic imaging-navigated photothermal therapy. Chinese Chemical Letters, 2026, 37(6): 111509-. doi: 10.1016/j.cclet.2025.111509
5. [5]
  Yuliang Yang , Jingyi Zhang , Yu Wang , Huan Chen , Yijian Gao , Xiliang Li , Yingpeng Wan , Qi Zhao , Ning Li , Shengliang Li . Quintuple-acceptor engineering of anti-quenching conjugated oligomers for highly efficient NIR-Ⅱb imaging and phototheranostics. Chinese Chemical Letters, 2025, 36(11): 110834-. doi: 10.1016/j.cclet.2025.110834
6. [6]
  Yu Qin , Mingyang Huang , Chenlu Huang , Hannah L. Perry , Linhua Zhang , Dunwan Zhu . O₂-generating multifunctional polymeric micelles for highly efficient and selective photodynamic-photothermal therapy in melanoma. Chinese Chemical Letters, 2024, 35(7): 109171-. doi: 10.1016/j.cclet.2023.109171
7. [7]
  Mengyao Gao , Shan Sun , Hengwei Lin , Cheng Yang . A multifunctional carbon dot-based nanoplatform for antibacterial therapy: Integrating photodynamic, photothermal, and gas treatments. Chinese Chemical Letters, 2026, 37(2): 111055-. doi: 10.1016/j.cclet.2025.111055
8. [8]
  Zhenjian Li , Xue Wu , Lingyun Li , Bingzhe Wang , Guichuan Xing , Yupeng Liu , Songnan Qu . Red and near-infrared emissive nitrogen-sulfur co-doped carbonized nanoparticles for red laser-induced synergistic photothermal and photodynamic tumor therapy. Chinese Chemical Letters, 2026, 37(5): 111501-. doi: 10.1016/j.cclet.2025.111501
9. [9]
  Bei Liu , Weizhe Xu , Wenfei Xu , Lirong Sun , Fanling Zhang , Zhaogang Sun , Yucheng Cheng , Hongqian Chu . Boosting the photodynamic therapy efficiency by modulating lactate-fueled respiration using a hollow MOF nanostructure. Chinese Chemical Letters, 2026, 37(5): 111851-. doi: 10.1016/j.cclet.2025.111851
10. [10]
  Wei Zhou , Di He , Ning Liu , Ying Li , Wenzhao Han , Weiping Zhou , Siyu Zhang , Cong Yu . A PDI-based NIR-Ⅱ fluorescence imaging guided molecular phototheranostic platform for GSH-triggered gas therapy, mild photothermal therapy and NIR-activated photodynamic therapy. Chinese Chemical Letters, 2025, 36(11): 110854-. doi: 10.1016/j.cclet.2025.110854
11. [11]
  Yiling Li , Zekun Gao , Xiuxiu Yue , Minhuan Lan , Xiuli Zheng , Benhua Wang , Shuang Zhao , Xiangzhi Song . FRET-based two-photon benzo[a] phenothiazinium photosensitizer for fluorescence imaging-guided photodynamic therapy. Chinese Chemical Letters, 2024, 35(7): 109133-. doi: 10.1016/j.cclet.2023.109133
12. [12]
  Yanyan Ma , Lizhen Xu , Muxin Xu , Jie Niu , Wei Xu , Weiying Lin . All in one: An in-situ activated tumor theranostic agent for NIR-Ⅱ fluorescence imaging guided surgical resection and photothermal therapy. Chinese Chemical Letters, 2025, 36(11): 110850-. doi: 10.1016/j.cclet.2025.110850
13. [13]
  Lulu He , Le Wang , Zhen He , Yiqian Yang , Cheng Heng Pang , Aiguo Wu , Bencan Tang , Juan Li . An imine-linked covalent organic framework with intrinsic photo-induced mitochondrial regulation for breast cancer therapy. Chinese Chemical Letters, 2025, 36(9): 110717-. doi: 10.1016/j.cclet.2024.110717
14. [14]
  Hui Guo , Wen-Wen Li , Mei-Yin Wu , Jian-Bo Hu , Jun Wang , Yun Liu , Yang Zou , Chu-Luo Yang , Kai-Lu Zheng . Indolizine-benzophenone hybrid acceptors enable TADF materials for bioimaging and photodynamic therapy in living cells. Chinese Chemical Letters, 2026, 37(1): 111721-. doi: 10.1016/j.cclet.2025.111721
15. [15]
  Baoli Yin , Xinlin Liu , Zhe Li , Zhifei Ye , Youjuan Wang , Xia Yin , Sulai Liu , Guosheng Song , Shuangyan Huan , Xiao-Bing Zhang . Ratiometric NIR-Ⅱ fluorescent organic nanoprobe for imaging and monitoring tumor-activated photodynamic therapy. Chinese Chemical Letters, 2025, 36(5): 110119-. doi: 10.1016/j.cclet.2024.110119
16. [16]
  Mingrui Zhang , Lingyu Jin , Yuda Zhu , Junfeng Kou , Bo Liu , Jing Chen , Xiaolin Zhong , Xianghua Wu , Junfeng Zhang , Wenxiu Ren . A near-infrared Ⅱ fluorescent dye based on oxanthracene: Real-time imaging of drug-induced acute liver injury and photothermal therapy for tumor. Chinese Chemical Letters, 2025, 36(10): 110772-. doi: 10.1016/j.cclet.2024.110772
17. [17]
  Lei Li , Annan Liu , Gang Wei , Xingchen Li , Hao Liang , Maja D. Nešić , Ze Wang , Hui Guo , Quan Lin . Advanced nanosystem for target recognition and precise dual-mode imaging-guided photothermal therapy against triple-negative breast cancer. Chinese Chemical Letters, 2026, 37(2): 110961-. doi: 10.1016/j.cclet.2025.110961
18. [18]
  Mengxing Liu , Jing Liu , Hongxing Zhang , Lijuan Wang , Jianan Tao , Wei Guo . Augmenting heptamethine cyanine photosensitivity while retaining strong fluorescence emission: Forming dye-albumin nanocomplex enables tumor-targeted photodynamic therapy. Chinese Chemical Letters, 2026, 37(4): 111141-. doi: 10.1016/j.cclet.2025.111141
19. [19]
  Zhong Du , Li-Jun Zhu , Jia-Bao Xiong , Yu-Xiang Gao , Ya-Qi Cui , Maierhaba Aili , Chen-Yang Chu , Chi Zhang , Gao-Fei Huang , Xue-Liang Zhang , Nuernisha Alifu , Biao Dong . Multifunctional FA-PDA@ICG-Bi₂Se₃ nanoplatform for targeted NIR and X-ray dual-modal imaging and photothermal therapy of cervical cancer. Chinese Chemical Letters, 2026, 37(4): 111488-. doi: 10.1016/j.cclet.2025.111488
20. [20]
  Yiqiao Chen , Ao Liu , Biwen Yang , Zhenzhen Li , Binggang Ye , Zhouyi Guo , Zhiming Liu , Haolin Chen . Photoluminescence and photothermal conversion in boric acid derived carbon dots for targeted microbial theranostics. Chinese Chemical Letters, 2024, 35(9): 109295-. doi: 10.1016/j.cclet.2023.109295

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沈阳化工大学材料科学与工程学院沈阳 110142