Citation: Lulu He, Le Wang, Zhen He, Yiqian Yang, Cheng Heng Pang, Aiguo Wu, Bencan Tang, Juan Li. An imine-linked covalent organic framework with intrinsic photo-induced mitochondrial regulation for breast cancer therapy[J]. Chinese Chemical Letters, ;2025, 36(9): 110717. doi: 10.1016/j.cclet.2024.110717 shu

An imine-linked covalent organic framework with intrinsic photo-induced mitochondrial regulation for breast cancer therapy

Lulu He ^{a, b, c, d} ,
Le Wang ^{b, c} ,
Zhen He ^{b, c} ,
Yiqian Yang ^{b, c} ,
Cheng Heng Pang ^{a, *,} ,
Aiguo Wu ^{b, c, d, *,} ,
Bencan Tang ^{a, *,} ,
Juan Li ^{b, c, d, *,}

a.
Department of Chemical and Environment Engineering, The University of Nottingham Ningbo China, Ningbo 315100, China
b.
Laboratory of Advanced Theranostic Materials and Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China
c.
Ningbo Cixi Institute of Biomedical Engineering, Cixi 315300, China
d.
Advanced Energy Science and Technology Guangdong Laboratory, Huizhou 516000, China

Chengheng.Pang@nottingham.edu.cn

aiguo@nimte.ac.cn

Bencan.Tang@nottingham.edu.cn

lij@nimte.ac.cn

Received Date: 12 August 2024
Revised Date: 27 November 2024
Accepted Date: 3 December 2024
Available Online: 9 December 2024

Figures(6)

Majority of photodynamic therapy (PDT) or photothermal therapy (PTT) is achieved by the integration of photosensitizers or photothermal agents into nanocarriers, which may bring risks due to uncertain leakage with serious nonspecific damage to normal tissues. Thus, we report an imine-linked nanoscale covalent organic framework (COF) with intrinsic photo-response ability, showing a high singlet oxygen generation ability by 660 nm irradiation, followed by the surface fabrication of polydopamine (PDA) that displays an excellent photothermal conversion performance under 808 nm irradiation. Furthermore, therapeutic agents with the modulation capacity of subcellular organelle such as mitochondria, shows more precision and effectiveness in cancer therapy. Herein, the obtained COF@PDA nanoplatform not only provides an excellent PDT/PTT-in-one therapeutic effect on inhibition of MCF-7 cancer cells, but also gives a prominent photo-induced mitochondrial regulation performance for enhanced treatment.
- Covalent organic framework,
- Mitochondrial regulation,
- Photodynamic therapy,
- Photothermal therapy,
- Breast cancer
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