Citation: Can Wang, Zhe Sun, Donghan Ma. Review of imaging buffers used in stochastic optical reconstruction microscopy[J]. Chinese Chemical Letters, ;2025, 36(9): 110677. doi: 10.1016/j.cclet.2024.110677 shu

Review of imaging buffers used in stochastic optical reconstruction microscopy

Can Wang ^{a, b} ,
Zhe Sun ^{b, c} ,
Donghan Ma ^{a, *,}

a.
School of Optoelectronic Engineering and Instrumentation Science, Dalian University of Technology, Dalian 116024, China
b.
School of Biomedical Engineering, Faculty of Medicine, Dalian University of Technology, Dalian 116024, China
c.
Cancer Hospital of Dalian University of Technology (Liaoning Cancer Hospital & Institute), Shenyang 110042, China

madonghan@dlut.edu.cn

Received Date: 30 August 2024
Revised Date: 19 November 2024
Accepted Date: 25 November 2024
Available Online: 26 November 2024

Figures(7)

Stochastic optical reconstruction microscopy (STORM), as a typical technique of single-molecule localization microscopy (SMLM), has overcome the diffraction limit by randomly switching fluorophores between fluorescent and dark states, allowing for the precise localization of isolated emission patterns and the super-resolution reconstruction from millions of localized positions of single fluorophores. A critical factor influencing localization precision is the photo-switching behavior of fluorophores, which is affected by the imaging buffer. The imaging buffer typically comprises oxygen scavengers, photo-switching reagents, and refractive index regulators. Oxygen scavengers help prevent photobleaching, photo-switching reagents assist in facilitating the conversion of fluorophores, and refractive index regulators are used to adjust the refractive index of the solution. The synergistic interaction of these components promotes stable blinking of fluorophores, reduces irreversible photobleaching, and thereby ensures high-quality super-resolution imaging. This review provides a comprehensive overview of the essential compositions and functionalities of imaging buffers used in STORM, serving as a valuable resource for researchers seeking to select appropriate imaging buffers for their experiments.
- Single-molecule localization microscopy,
- Stochastic optical reconstruction microscopy,
- Photo-switching,
- Photobleaching,
- Imaging buffer
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沈阳化工大学材料科学与工程学院沈阳 110142