Citation: Xicheng Li, Dong Mo, Shoushan Hu, Meng Pan, Meng Wang, Tingyu Yang, Changxing Qu, Yujia Wei, Jianan Li, Hanzhi Deng, Zhongwu Bei, Tianying Luo, Qingya Liu, Yun Yang, Jun Liu, Jun Wang, Zhiyong Qian. A Pt@ZIF-8/ALN-ac/GelMA composite hydrogel with antibacterial, antioxidant, and osteogenesis for periodontitis[J]. Chinese Chemical Letters, ;2025, 36(9): 110674. doi: 10.1016/j.cclet.2024.110674 shu

A Pt@ZIF-8/ALN-ac/GelMA composite hydrogel with antibacterial, antioxidant, and osteogenesis for periodontitis

Xicheng Li ^a ,
Dong Mo ^a ,
Shoushan Hu ^b ,
Meng Pan ^a ,
Meng Wang ^a ,
Tingyu Yang ^a ,
Changxing Qu ^b ,
Yujia Wei ^a ,
Jianan Li ^a ,
Hanzhi Deng ^a ,
Zhongwu Bei ^a ,
Tianying Luo ^a ,
Qingya Liu ^a ,
Yun Yang ^a ,
Jun Liu ^b ,
Jun Wang ^b ,
Zhiyong Qian ^{a, *,}

a.
Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
b.
State Key Laboratory of Oral Diseases and National Center for Stomatology and National Clinical Research Center for Oral Diseases and Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

anderson-qian@163.com

Received Date: 3 August 2024
Revised Date: 15 November 2024
Accepted Date: 22 November 2024
Available Online: 23 November 2024

Figures(8)

Periodontitis is a chronic inflammatory disease caused by oral pathogens, and the osteogenic potential of human periodontal ligament stem cells (hPDLSCs) is severely impaired under the inflammatory environment. Current clinical periodontitis treatment strategies such as surgical interventions and antibiotic delivery still suffer from poor antibacterial efficacy, difficulty in ameliorating excessive inflammatory responses and slow periodontal tissue regeneration. Here, we have innovatively developed a non-surgical treatment strategy based on a functional composite hydrogel. A composite hydrogel system (Pt@ZIF-8/ALN-ac/Gel) containing bioactive zeolite imidazolate framework-8 (ZIF-8) integrated with platinum nanoparticles (Pt@ZIF-8) and alendronate acrylamide (ALN-ac) was constructed on the basis of gelatin methacryloyl (GelMA) to achieve enhanced antibacterial effect and reactive oxygen species (ROS) scavenging ability while promoting the osteogenic potential of hPDLSCs. We confirmed that Pt@ZIF-8/ALN-ac/Gel was able to continuously release Zn²⁺ and exerted an obvious antibacterial effect against Porphyromonas gingivalis. In vitro experiments proved that Pt@ZIF-8/ALN-ac/Gel had good biocompatibility, while efficiently featuring excellent reactive oxygen species (ROS) scavenging capacity, increasing alkaline phosphatase activity, and promoting extracellular matrix mineralization by hPDLSCs. In vivo, Pt@ZIF-8/ALN-ac/Gel significantly inhibited the alveolar bone deterioration and reduced osteoclast activation and inflammation, thereby promoting the regeneration of damaged tissues. These findings demonstrated superior therapeutic efficacy in the reported clinical periodontitis treatment, exhibiting great potential for application.
- ZIF-8,
- Reactive oxygen species,
- Hydrogel,
- Antibacterial,
- Alendronate,
- Periodontal regeneration
1. [1]
  B. Pihlstrom, B. Michalowicz, N. Johnson, Lancet 366 (2005) 1809–1820. doi: 10.1016/S0140-6736(05)67728-8
2. [2]
  C. Ren, X. Hao, L. Wang, et al., Adv. Healthc. Mater. 10 (2021) 2100196. doi: 10.1002/adhm.202100196
3. [3]
  B. Zeng, Z. Mu, T. Shen, et al., Chin. Chem. Lett. 36 (2025) 110350. doi: 10.1016/j.cclet.2024.110350
4. [4]
  D. Richards, Evid. Based Dent. 15 (2014) 70–71. doi: 10.1038/sj.ebd.6401037
5. [5]
  J. Li, S. Song, J. Meng, et al., J. Am. Chem. Soc. 143 (2021) 15427–15439. doi: 10.1021/jacs.1c07875
6. [6]
  L. Wu, S. Zhang, L. Zhao, Z. Ren, C. Hu, J. Periodontol. 93 (2022) 1445–1454. doi: 10.1002/JPER.21-0469
7. [7]
  Y. Xu, Y. Luo, Z. Weng, et al., ACS Nano 17 (2023) 18732–18746. doi: 10.1021/acsnano.3c01940
8. [8]
  J. Gong, C. Ye, J. Ran, et al., ACS Nano 17 (2023) 16573–16586. doi: 10.1021/acsnano.3c02407
9. [9]
  G. Hajishengallis, Nat. Rev. Immunol. 15 (2015) 30–44. doi: 10.1038/nri3785
10. [10]
  L.M. Silva, A.D. Doyle, T. Greenwell-Wild, et al., Science 374 (2021) eabl5450. doi: 10.1126/science.abl5450
11. [11]
  D. Herrera, P. Matesanz, C. Martín, et al., J. Clin. Periodontol. 47 (2020) 239–256. doi: 10.1111/jcpe.13230
12. [12]
  P. Angst, A. Stadler, M. Mendez, R. Oppermann, U. Velden, S. Gomes, J. Clin. Periodontol. 46 (2019) 1083–1093. doi: 10.1111/jcpe.13178
13. [13]
  F. Graziani, D. Karapetsa, B. Alonso, D. Herrera, Periodontology 2000 75 (2017) 152–188. doi: 10.1111/prd.12201
14. [14]
  F. Graziani, L. Music, D. Bozic, G. Tsakos, Br. Dent. J. 227 (2019) 621–625. doi: 10.1038/s41415-019-0735-3
15. [15]
  D. Mo, M. Pan, W. Chen, et al., Adv. Funct. Mater. 34 (2024) 2313569. doi: 10.1002/adfm.202313569
16. [16]
  M. Zhang, X. Peng, H. Xu, et al., Adv. Sci. 11 (2024) 2404143. doi: 10.1002/advs.202404143
17. [17]
  H. Wang, K. Wan, X. Shi, Adv. Mater. 31 (2019) 1805368. doi: 10.1002/adma.201805368
18. [18]
  G. Tarricone, V. Castagnola, V. Mastronardi, et al., Nano Lett. 23 (2023) 4660–4668. doi: 10.1021/acs.nanolett.3c01479
19. [19]
  J. Mu, C. Li, Y. Shi, et al., Nat. Commun. 13 (2022) 2513. doi: 10.1038/s41467-022-29772-w
20. [20]
  D. Pedone, M. Moglianetti, E. De Luca, G. Bardi, P.P. Pompa, Chem. Soc. Rev. 46 (2017) 4951–4975. doi: 10.1039/C7CS00152E
21. [21]
  F. Xia, X. Hu, B. Zhang, et al., Small 18 (2022) 2201558. doi: 10.1002/smll.202201558
22. [22]
  X. Ji, Q. Li, H. Song, C. Fan, Adv. Mater. 34 (2022) 2201562. doi: 10.1002/adma.202201562
23. [23]
  P. Horcajada, R. Gref, T. Baati, et al., Chem. Rev. 112 (2012) 1232–1268. doi: 10.1021/cr200256v
24. [24]
  Y. Guo, S. Ding, C. Shang, et al., Adv. Mater. 36 (2024) 2306292. doi: 10.1002/adma.202306292
25. [25]
  Y. Wan, J. Fang, Y. Wang, et al., Adv. Healthc. Mater. 10 (2021) 2101515. doi: 10.1002/adhm.202101515
26. [26]
  L. He, G. Huang, H. Liu, et al., Sci. Adv. 6 (2020) eaay9751. doi: 10.1126/sciadv.aay9751
27. [27]
  Y. Liu, Z. Zhu, X. Pei, et al., ACS Appl. Mater. Interfaces 12 (2020) 36978–36995. doi: 10.1021/acsami.0c12090
28. [28]
  D. Mo, Z. Wang, K. Sun, et al., J. Mater. Chem. C 8 (2020) 11110–11118. doi: 10.1039/D0TC00908C
29. [29]
  W. Wang, S. Chen, E. Guisasola Cal, et al., Inorg. Chem. Front. 7 (2020) 3945–3952. doi: 10.1039/D0QI00831A
30. [30]
  T. Luo, H. Yang, R. Wang, et al., ACS Nano 17 (2023) 16715–16730. doi: 10.1021/acsnano.3c03169
31. [31]
  K. Zhou, Z. Shi, X. Yi, et al., Chin. Chem. Lett. 36 (2025) 110226. doi: 10.1016/j.cclet.2024.110226
32. [32]
  H. Wang, S. Chen, Z. He, et al., Chin. Chem. Lett. 35 (2024) 108597. doi: 10.1016/j.cclet.2023.108597
33. [33]
  D. Steinberg, M. Friedman, Periodontology 2000 84 (2020) 176–187. doi: 10.1111/prd.12341
34. [34]
  Y. Liu, T. Li, M. Sun, et al., Acta Biomater 146 (2022) 37–48. doi: 10.1016/j.actbio.2022.03.046
35. [35]
  B. Maharjan, D. Kumar, G.P. Awasthi, et al., Composites Part B 177 (2019) 107415. doi: 10.1016/j.compositesb.2019.107415
36. [36]
  T. Yu, Y. Hu, W. He, et al., Materials Today Bio. 19 (2023) 100558. doi: 10.1016/j.mtbio.2023.100558
37. [37]
  W. Shi, X. Zhang, L. Bian, et al., Int. J. Biol. Macromol. 204 (2022) 441–456. doi: 10.1016/j.ijbiomac.2022.02.007
38. [38]
  R. Wang, L. Che, Q. Feng, K. Cai, ACS Appl. Mater. Interfaces 14 (2022) 12038–12049. doi: 10.1021/acsami.1c23017
39. [39]
  L. Xue, N. Gong, S.J. Shepherd, et al., J. Am. Chem. Soc. 144 (2022) 9926–9937. doi: 10.1021/jacs.2c02706
40. [40]
  Q. Yao, Y. Liu, Y. Pan, et al., J. Colloid Interface Sci. 607 (2022) 1500–1515. doi: 10.1016/j.jcis.2021.09.089
41. [41]
  L. Yang, X. Chen, L. Chen, et al., Macromol. Biosci. 24 (2024) 2300416. doi: 10.1002/mabi.202300416
42. [42]
  J. Abtahi, F. Agholme, O. Sandberg, P. Aspenberg, J. Dent. Res. 92 (2013) 279–283. doi: 10.1177/0022034512472335
43. [43]
  J. Li, L. Li, T. Wu, et al., Small Methods 8 (2024) e2300843. doi: 10.1002/smtd.202300843
44. [44]
  Y. Qu, B. Chu, J. Li, et al., Small Methods 8 (2024) e2301178. doi: 10.1002/smtd.202301178
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2. [2]
  Min ZHU , Yuxin WANG , Xiao LI , Yaxu XU , Junwen ZHU , Zihao WANG , Yu ZHU , Xiaochen HUANG , Dan XU , Monsur Showkot Hossain Abul . Construction of AgVO₃/ZIF-8 composites for enhanced degradation of tetracycline. Chinese Journal of Inorganic Chemistry, 2025, 41(5): 994-1006. doi: 10.11862/CJIC.20240392
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4. [4]
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5. [5]
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6. [6]
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7. [7]
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8. [8]
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9. [9]
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10. [10]
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11. [11]
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12. [12]
  Mengyi Xi , Kaiqing Wu , Jingjing Chen , Yanfei Shen , Songqin Liu , Ran Chen , Yuanjian Zhang . Recent advances of analytical methods for intermediates of reactive oxygen species in electrocatalytic oxygen reduction reactions. Chinese Chemical Letters, 2026, 37(5): 111915-. doi: 10.1016/j.cclet.2025.111915
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  Xiaokang Hou , Huanxin Ma , Mengmeng Zhao , Chunhua Feng , Shishu Zhu . Unveiling role of Cu(Ⅱ) in photochemical transformation and reactive oxygen species production of schwertmannite in the presence of tartaric acid. Chinese Chemical Letters, 2025, 36(7): 110332-. doi: 10.1016/j.cclet.2024.110332
14. [14]
  Xiaoliu Liang , Chunliu Huang , Hui Liu , Hu Chen , Jiabao Shou , Hongwei Cheng , Gang Liu . Natural hydrogel dressings in wound care: Design, advances, and perspectives. Chinese Chemical Letters, 2024, 35(10): 109442-. doi: 10.1016/j.cclet.2023.109442
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17. [17]
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沈阳化工大学材料科学与工程学院沈阳 110142