Citation: Changmin Liu, Ying Wang, Yongqi Bao, Yuqing Lin. Metal-organic framework mimetic enzymes: Exploring new horizons in brain chemistry[J]. Chinese Chemical Letters, ;2025, 36(9): 110652. doi: 10.1016/j.cclet.2024.110652 shu

Metal-organic framework mimetic enzymes: Exploring new horizons in brain chemistry

Department of Chemistry, Capital Normal University, Beijing 100048, China

linyuqing@cnu.edu.cn

Received Date: 16 July 2024
Revised Date: 5 October 2024
Accepted Date: 13 November 2024
Available Online: 14 November 2024

Figures(10)

Natural enzymes are able to precisely bind substrates and catalyze activities because of their distinct framework structures. To mimic this ability, chemists are designing framework structures that resemble real enzymes. The use of metal-organic frameworks (MOFs) to mimic natural enzymes has advanced recently; this paper reviews these developments. This research specifically focuses on how the catalytically active center of natural enzymes can be exactly replicated by carefully controlling the composition and structure of MOFs. By identifying and attaching to substrates, MOFs can accelerate changes in a manner akin to that of real enzymes. The role of MOFs in simulating catalytic processes, enzyme activity, and potential uses in brain chemistry are also investigated in this work. It also discusses the most recent MOF applications in detecting and treating chemical abnormalities of the brain. The report finishes with a discussion of future research areas and potential applications, providing useful insights for researchers in the subject.
- Natural enzymes,
- Mimicking enzymes,
- Metal-organic frameworks,
- Chemical catalysis,
- Brain chemistry
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沈阳化工大学材料科学与工程学院沈阳 110142