Citation: Yuyao Guan, Baoting Yu, Jun Ding, Tingting Sun, Zhigang Xie. BODIPY photosensitizers for antibacterial photodynamic therapy[J]. Chinese Chemical Letters, ;2025, 36(8): 110645. doi: 10.1016/j.cclet.2024.110645 shu

BODIPY photosensitizers for antibacterial photodynamic therapy

Yuyao Guan ^a ,
Baoting Yu ^a ,
Jun Ding ^{a, *,} ,
Tingting Sun ^{b, *,} ,
Zhigang Xie ^b

a.
Department of Radiology, China−Japan Union Hospital of Jilin University, Changchun 130033, China
b.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

dingjun@jlu.edu.cn

suntt@ciac.ac.cn

Received Date: 6 September 2024
Revised Date: 4 November 2024
Accepted Date: 11 November 2024
Available Online: 12 November 2024

Figures(13)

Bacterial infections pose a significant threat to human health and entail substantial economic losses. Due to the broad-spectrum antibacterial effect and low susceptibility to drug resistance, photodynamic therapy (PDT), a nontraditional antibacterial approach, has garnered a lot of attention. In PDT, the selection of photosensitizer (PS) is crucial because it directly affects the efficiency and safety of the treatment. As a versatile fluorophore, the advantages of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) used as a PS for antibacterial PDT are mainly reflected in its high quantum yield of singlet oxygen, easy modification, and exceptional photostability. Through strategic chemical modifications of the BODIPY structures, it is possible to enhance their photodynamic antibacterial activity and refine their selectivity for bacterial killing. This review focuses on the application of BODIPY-based PSs for treating bacterial infections. According to the design strategies of photodynamic antibacterial materials incorporating BODIPY, a variety of representative therapeutic agents having emerged in recent years are classified and discussed, aiming to offer insights for future research and development in this field.
- BODIPY,
- Photodynamic therapy,
- Antibacterial,
- Antimicrobial,
- Reactive oxygen species
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沈阳化工大学材料科学与工程学院沈阳 110142