Citation: Chong Wang, Hao Xie, Rulan Xia, Xuewei Liao, Jin Wang, Huajun Yang, Chen Wang. Nanofluidic ion rectification sensor for enantioselective recognition and detection[J]. Chinese Chemical Letters, ;2025, 36(8): 110642. doi: 10.1016/j.cclet.2024.110642 shu

Nanofluidic ion rectification sensor for enantioselective recognition and detection

Chong Wang ^a ,
Hao Xie ^a ,
Rulan Xia ^a ,
Xuewei Liao ^{a, b, *,} ,
Jin Wang ^a ,
Huajun Yang ^a ,
Chen Wang ^{a, *,}

a.
Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of New Power Batteries, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China
b.
Analytical & Testing Center, Nanjing Normal University, Nanjing 210023, China

liaoxuewei@njnu.edu.cn

wangchen@njnu.edu.cn

Received Date: 5 August 2024
Revised Date: 11 October 2024
Accepted Date: 9 November 2024
Available Online: 10 November 2024

Figures(6)

Enantiomer identification is of paramount industrial value and physiological significance. Construction of sensitive chiral sensors with high enantiomeric discrimination ability is highly desirable. In this work, a chiral covalent organic framework/anodic aluminum oxide (c-COF/AAO) membrane was prepared for electrochemical enantioselective recognition and sensing. Benefiting from the remarkable asymmetry, the as-prepared nanofluidic c-COF/AAO presents a distinct ion current rectification (ICR) characteristic, enabling sensitive bioanalysis. In addition, owing to the large surface area, high chemical stability and perfect ion selectivity of chiral COF, the prepared c-COF/AAO membrane presents exceptionally selective mass transport and thereby enables excellent chiral discrimination for S-/R-Naproxen (S-/R-Npx) enantiomers. It is especially noteworthy that the detection limit is achieved as low as 3.88 pmol/L. These results raise the possibility for a facile, stable and low-cost method to carry out sensitive enantioselective recognition and detection.
- Nanofluidic sensor,
- Chiral recognition,
- Ion current rectification (ICR),
- Covalent organic framework,
- Electrochemical detection
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