Citation: Zeyang Yao, Xinru You, Xudong Wang, Yunze Kang, Liying Wang, Ziji Zhang. Stem cell-based hydrogel for the repair and regeneration of cartilage[J]. Chinese Chemical Letters, ;2025, 36(8): 110607. doi: 10.1016/j.cclet.2024.110607 shu

Stem cell-based hydrogel for the repair and regeneration of cartilage

Zeyang Yao ^{a, b, 1} ,
Xinru You ^{c, 1} ,
Xudong Wang ^{a, b, 1} ,
Yunze Kang ^{a, b} ,
Liying Wang ^{d, *,} ,
Ziji Zhang ^{a, b, *,}

a.
Department of Orthopaedics, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
b.
Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, Guangzhou 510080, China
c.
Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States
d.
Department of Hematology, the Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China

wangly53@mail2.sysu.edu.cn

zhangziji@mail.sysu.edu.cn

Received Date: 28 August 2024
Revised Date: 23 October 2024
Accepted Date: 1 November 2024
Available Online: 1 November 2024

Figures(6)

Repairing and regenerating cartilage defects in osteoarthritis patients remains challenging. Traditional treatments primarily offer symptom relief without addressing the underlying progression of the disease. Stem cell therapies provide a promising solution, yet they face limitations such as short retention times, low survival rates in vivo, and insufficient extracellular matrix (ECM) production. Stem cell-based hydrogel therapy offers a controlled microenvironment that can mitigate these challenges and enhance cell therapy effectiveness. This review evaluates the advantages and limitations of various stem cell types and hydrogel materials, summarizing recent advances in their combination for cartilage repair. The potential of stem cell-hydrogel therapies is highlighted, along with the remaining challenges and future directions for improving their clinical application.
- Stem cell,
- Hydrogel,
- Cartilage,
- Osteoarthritis,
- Tissue engineering
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