Citation: Wenya Chi, Ruiyao Liu, Wenbo Zhou, Weilin Li, Yuan Yu. The mechanisms of interaction between biomaterials and cells/cellular microenvironment and the applications in neural injuries[J]. Chinese Chemical Letters, ;2025, 36(8): 110587. doi: 10.1016/j.cclet.2024.110587 shu

The mechanisms of interaction between biomaterials and cells/cellular microenvironment and the applications in neural injuries

Wenya Chi ^a ,
Ruiyao Liu ^a ,
Wenbo Zhou ^a ,
Weilin Li ^a ,
Yuan Yu ^{a, b, *,}

a.
Department of Pharmaceutical Science, Faculty of Pharmacy, Naval Medical University, Shanghai 200433, China
b.
The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), Shanghai 200433, China

pharmyuu@163.com

Received Date: 8 July 2024
Revised Date: 22 October 2024
Accepted Date: 28 October 2024
Available Online: 29 October 2024

Figures(6)

Neural injuries can be induced by various neurological disorders and traumas, such as brain and spinal cord injuries, cerebrovascular diseases, and neurodegeneration. Due to the designable physicochemical properties, biomaterials are applied for various purposes in neural repair, including promoting axonal regeneration, reducing glial scar formation, delivering drugs, and providing temporary mechanical support to the injured tissue. They need to match the extracellular matrix (ECM) environment, support three-dimensional (3D) cell growth, repair the cellular microenvironment, mimic the tissue's biomechanical forces, and possess biodegradability and plasticity suitable for local intracavity applications. Meanwhile, functionalized biomaterials have been conducted to mimic the structural components of cellular ecological niches and the specific functions of the ECM. They can be engineered to carry a variety of bioactive components, such as stem cells and extracellular vesicles, which are used in neuroscience-related tissue engineering. Researchers also have developed biomaterial-based brain-like organs for high-throughput drug screening and pathological mechanistic studies. This review will discuss the interactions between biomaterials and cells, as well as the advances in neural injuries and engineered microtissues.
- Biomaterial,
- Neural injury,
- Extracellular matrix,
- Bioscaffold,
- Nano-drug delivery system,
- Microtissue
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沈阳化工大学材料科学与工程学院沈阳 110142