Citation: Xue-Wen Wu, Bin-Bao Wang, Yu Qin, Yong-Xiang Huang, Muhammad Aurang Zeb, Bin Cheng, Xiao-Li Li, Chang-Bo Zheng, Wei-Lie Xiao. Diterpenoids with unexpected 5/6/6-fused ring system and its dimer from Strophioblachia glandulosa[J]. Chinese Chemical Letters, ;2025, 36(8): 110584. doi: 10.1016/j.cclet.2024.110584 shu

Diterpenoids with unexpected 5/6/6-fused ring system and its dimer from Strophioblachia glandulosa

Xue-Wen Wu ^{a, 1} ,
Bin-Bao Wang ^{b, 1} ,
Yu Qin ^a ,
Yong-Xiang Huang ^c ,
Muhammad Aurang Zeb ^a ,
Bin Cheng ^a ,
Xiao-Li Li ^{a, *,} ,
Chang-Bo Zheng ^{c, *,} ,
Wei-Lie Xiao ^{a, d, *,}

a.
Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Research & Development Center for Natural Products, School of Chemical Science and Technology, and School of Pharmacy, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming 650091, China
b.
Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, China
c.
School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China
d.
Southwest United Graduate School, Kunming 650592, China

lixiaoli@ynu.edu.cn

zhengchangbo@kmmu.edu.cn

xiaoweilie@ynu.edu.cn

Received Date: 23 August 2024
Revised Date: 22 October 2024
Accepted Date: 27 October 2024
Available Online: 29 October 2024

Figures(4)

Six rearranged nor-diterpenoids with 5/6/6-fused tricyclic system (1–6), and one unprecedented dimer with 5/6/6/6/6/5-fused carbon core (7) were isolated from Strophioblachia glandulosa. Spectroscopic techniques, electronic circular dichroism (ECD), quantum chemical calculations, and single-crystal X-ray diffraction analysis were used to elucidate their structures. A preliminary bioactivity assay revealed compounds 2 and 3 exhibited potent anti-myocardial hypertrophy effect in vitro by significantly inhibiting the expression levels of atrial natriuretic peptide (ANP) and myosin heavy chain 7 (MYH7) proteins. Additionally, mitogen-activated protein kinase 14 (Mapk14) may be involved in the regulation of compound 3 on cardiac hypertrophic disease by network pharmacology prediction and experimental verification.
- Strophioblachia glandulosa,
- Diterpenoid,
- Dimer,
- Cardiac hypertrophy,
- Network pharmacology
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沈阳化工大学材料科学与工程学院沈阳 110142