Citation: Yixin Sun, Keke Yu, Xiuchun Guo, Lanlan Zong, Zhonggui He, Xiaohui Pu. Three-in-one reduction and acid-ignited micelles amplify antitumor efficacy via precise synergistic delivery of paclitaxel and naringenin[J]. Chinese Chemical Letters, ;2025, 36(6): 110393. doi: 10.1016/j.cclet.2024.110393 shu

Three-in-one reduction and acid-ignited micelles amplify antitumor efficacy via precise synergistic delivery of paclitaxel and naringenin

Yixin Sun ^{a, b} ,
Keke Yu ^a ,
Xiuchun Guo ^a ,
Lanlan Zong ^{a, c, *,} ,
Zhonggui He ^{a, b, *,} ,
Xiaohui Pu ^{a, c, *,}

a.
State Key Laboratory of Antiviral Drugs, Henan Province Engineering Research Center of High Value Utilization to Natural Medical Resource in Yellow River Basin, School of Pharmacy, Henan University, Kaifeng 475004, China
b.
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China
c.
Huaihe Hospital of Henan University, Kaifeng 475004, China

lanlan198903@126.com

hezhgui_student@aliyun.com

pgh425@163.com

Received Date: 7 June 2024
Revised Date: 29 August 2024
Accepted Date: 30 August 2024
Available Online: 31 August 2024

Figures(5)

Chemotherapy is the cornerstone of cancer treatment, and paclitaxel (PTX), as a first-line broad-spectrum chemotherapy drug, is widely used in the treatment of multiple tumors in the clinic. However, unsatisfactory efficacy and drug resistance of single chemotherapy have severely hampered the clinical progress of PTX. Herein, three-in-one naringenin (NAR)-loaded PTX polymer prodrug micelles were constructed for efficient and synergistic antitumor therapy. Firstly, the polymer prodrug micelles could simultaneously act as nanoreservoirs for two hydrophobic drugs, PTX and NAR. Secondly, the polymer prodrug micelles enabled dual-responsive intelligent release of PTX and NAR triggered by reduction and acid. Finally, released PTX and NAR exerted synergistic antitumor effects for reversing tumor resistance, while NAR enhanced the immune and anti-inflammatory functions of polymer prodrug micelles. Due to the cascade-enhanced chemotherapeutic augmentation, the intelligent-responsive nanoreservoir proved to be an excellent antitumor therapeutic platform. This work was of great interest for designing superior chemotherapeutic augmentation regimens.
- Polymer prodrug micelles,
- Synergistic delivery,
- PTX,
- NAR,
- Cancer therapy
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