Citation: Xueyan Zhen, Linhao Li, Lanlan Jia, Aihong Zhu, Yixuan Yang, Sicen Wang, Xiaoyu Xie. Biointerface engineering of self-protective bionic nanomissiles for targeted synergistic chemotherapy[J]. Chinese Chemical Letters, ;2023, 34(4): 107680. doi: 10.1016/j.cclet.2022.07.023 shu

Biointerface engineering of self-protective bionic nanomissiles for targeted synergistic chemotherapy

Xueyan Zhen ^{a, b} ,
Linhao Li ^{a, b} ,
Lanlan Jia ^{a, b} ,
Aihong Zhu ^{a, b} ,
Yixuan Yang ^{a, b} ,
Sicen Wang ^{a, b} ,
Xiaoyu Xie ^{a, b, *,}

a.
School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China
b.
Shaanxi Engineering Research Center of Cardiovascular Drugs Screening & Analysis, Xi'an 710061, China

xiexiaoyu@xjtu.edu.cn

Received Date: 24 January 2022
Revised Date: 11 July 2022
Accepted Date: 12 July 2022
Available Online: 14 July 2022

Figures(4)

Erythrocyte membrane (EM)-camouflaged chemotherapeutic delivery nanovehicles hold promise for solid tumor therapy because of their excellent biostability and biocompatibility. However, it is accompanied with insufficient targeting effect and deficient pharmacokinetic behavior due to the lack of a regulated biointerface to navigate and overcome biological transportation obstacles in solid tumor therapy. Herein, an anti-epidermal growth factor receptor (EGFR) aptamer (EApt) modified and EM-cloaked chemotherapeutic nanomissile delivery system was constructed. The anchored-EApt acting as a specific EGFR suppressor promotes to inhibit the overexpression of EGFR and initiate the cell apoptosis. Importantly, the resulting PLGA-DOX@EM-EApt orchestrated the bioactivity of each component and provided synergistic cell apoptosis and antitumor effects by precisely suppressing EGFR expression levels and delivering DOX. The in vitro and in vivo experimental results confirmed that the immune escape and active targeting behaviors of PLGA-DOX@EM-EApt could significantly promote its drug retention and tumor inhibition abilities. Our findings propose a novel strategy using the biointerface functionalization technique, demonstrating a promising therapeutic platform via a biomimetic drug delivery system for precise solid tumor recognition and synergistic therapy.
- Aptamer,
- Self-protective,
- Biointerface,
- Targeted drug delivery,
- Synergistic chemotherapy
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沈阳化工大学材料科学与工程学院沈阳 110142