Citation: Hangyan Yu, Han Lin, Yuntian Xie, Mengyuan Qu, Min Jiang, Jie Shi, Haofei Hong, Hongrui Xu, Ling Li, Guochao Liao, Zhimeng Wu, Zhifang Zhou. MUC1 vaccines using β-cyclodextrin grafted chitosan (CS-g-CD) as carrier via host-guest interaction elicit robust immune responses[J]. Chinese Chemical Letters, ;2022, 33(11): 4882-4885. doi: 10.1016/j.cclet.2022.02.072 shu

MUC1 vaccines using β-cyclodextrin grafted chitosan (CS-g-CD) as carrier via host-guest interaction elicit robust immune responses

Hangyan Yu ^a ,
Han Lin ^a ,
Yuntian Xie ^a ,
Mengyuan Qu ^a ,
Min Jiang ^a ,
Jie Shi ^a ,
Haofei Hong ^a ,
Hongrui Xu ^b ,
Ling Li ^b ,
Guochao Liao ^c ,
Zhimeng Wu ^a ,
Zhifang Zhou ^{a, *,}

a.
The Key Laboratory of Carbohydrate Chemistry & Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China
b.
Suzhou Municipal Center for Disease Control and Prevention, Suzhou 215004, China
c.
Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China

zhifangzhou@jiangnan.edu.cn

Received Date: 1 November 2021
Revised Date: 24 February 2022
Accepted Date: 25 February 2022
Available Online: 1 March 2022

Figures(5)

We construct MUC1 vaccines using β-cyclodextrin grafted chitosan (CS-g-CD) as carrier via host-guest interaction. These vaccines based on non-covalent assembling can provoke robust immune responses, including high level of specific antibodies and cytokines. The induced antibodies can specifically recognize tumor cells and mediate cytotoxicity against tumor cells. These results indicate that CS-g-CD with strong immunostimulatory activities can be a straightforward platform for peptide-based vaccine construction.
- β-Cyclodextrin grafted chitosan,
- MUC1 antigen,
- Cancer vaccine,
- Host-guest interaction,
- Vaccine carrier,
- Tn antigen
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