Citation: Jianyi Shi, Zheng Zeng, Shengting Xu, Zechun Cai, Yuehua Luo, Yongbo Fan, Zhongzhi Zhu, Tingting Wen, Xiuwen Chen. Cross-coupling of 2-methylquinolines and in-situ activated isoquinolines: Construction of 1,2-disubstituted isoquinolinones[J]. Chinese Chemical Letters, ;2022, 33(11): 4874-4877. doi: 10.1016/j.cclet.2022.02.032 shu

Cross-coupling of 2-methylquinolines and in-situ activated isoquinolines: Construction of 1,2-disubstituted isoquinolinones

Jianyi Shi ^{a, 1} ,
Zheng Zeng ^{b, 1} ,
Shengting Xu ^a ,
Zechun Cai ^a ,
Yuehua Luo ^a ,
Yongbo Fan ^a ,
Zhongzhi Zhu ^{a, *,} ,
Tingting Wen ^a ,
Xiuwen Chen ^{a, *,}

a.
School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China
b.
Affiliated Hospital of Guilin Medical University, Guilin 541001, China

wyuchemzzz@126.com

chenxiuwen2010@126.com

Received Date: 13 January 2022
Revised Date: 12 February 2022
Accepted Date: 14 February 2022
Available Online: 18 February 2022

Figures(7)

In this study, a method was developed to form C(sp³)–C(sp²) bonds via copper catalyst-promoted cross coupling of 2-methylquinoline and in-situ-activated 3-haloisoquinoline under mild conditions. The multi-component tandem reaction was used to construct new C–N, C=O and C–C bonds in one pot via sequential functionalization of the N1, C3 and C1 positions of 3-haloisoquinoline. This method can be used to efficiently access 1,2-disubstituted isoquinolinones by the three-component reaction of 3-halogen isoquinoline, alkyl halide, and 2-methylquinoline.
- Isoquinolinones,
- In-situ activated,
- Three-component reaction,
- One-pot,
- Trifunctionalisation
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