Citation: Wangmin Hu, Tianyi Li, Yulei Yang, Shanshan Jia, Mei Zhang. Rapid differentiation of simple saccharides based on cluster ions by paper spray tandem mass spectrometry[J]. Chinese Chemical Letters, ;2022, 33(11): 4808-4816. doi: 10.1016/j.cclet.2022.01.026 shu

Rapid differentiation of simple saccharides based on cluster ions by paper spray tandem mass spectrometry

Wangmin Hu ^{a, 1} ,
Tianyi Li ^{b, 1} ,
Yulei Yang ^a ,
Shanshan Jia ^a ,
Mei Zhang ^{a, *,}

a.
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China
b.
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China

meizhang@bucm.edu.cn

Received Date: 25 October 2021
Revised Date: 29 November 2021
Accepted Date: 11 January 2022
Available Online: 17 January 2022

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Simple saccharides have a variety of biological functions, but their structural diversity and inherent structural features pose a major challenge for rapid analysis. In this work, we developed a derivative-free and ion mobility-free method for the rapid analysis of monosaccharides and disaccharides using paper spray tandem mass spectrometry. Trimeric cluster ions consisting of saccharide analytes, ligands and transition metal ions are used as precursor ions. We defined the R-value as the ratio of the intensity of the product ion that loses one molecule of ligand over the intensity of the product ion that loses one molecule of saccharide via collision induced dissociation (CID). The species and conformation of simple saccharides can be easily differentiated by calculating this R-value. With the capability of directly analyzing clinical samples using paper spray ionization, our method can be used to rapidly quantify the molar ratio of galactose to glucose in dried plasma samples to aid in the diagnosis of galactosemia. The analytical strategy provided herein has good potential to be applied to a wide range of saccharide analysis applications in the future.
- Simple saccharide,
- Rapid structure differentiation,
- Paper spray,
- Tandem mass spectrometry
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