Citation: Hui Liu, Xi Xiang, Jianbo Huang, Bihui Zhu, Liyun Wang, Yuanjiao Tang, Fangxue Du, Ling Li, Feng Yan, Lang Ma, Li Qiu. Ultrasound augmenting injectable chemotaxis hydrogel for articular cartilage repair in osteoarthritis[J]. Chinese Chemical Letters, ;2021, 32(5): 1759-1764. doi: 10.1016/j.cclet.2020.12.004 shu

Ultrasound augmenting injectable chemotaxis hydrogel for articular cartilage repair in osteoarthritis

Hui Liu ^{a, b} ,
Xi Xiang ^a ,
Jianbo Huang ^a ,
Bihui Zhu ^a ,
Liyun Wang ^a ,
Yuanjiao Tang ^a ,
Fangxue Du ^a ,
Ling Li ^a ,
Feng Yan ^a ,
Lang Ma ^{a, *,} ,
Li Qiu ^{a, *,}

a.
Department of Ultrasound, Laboratory of Ultrasound Imaging Drug, West China Hospital, Sichuan University, Chengdu 610041, China
b.
Department of Ultrasound, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China

malang1989@scu.edu.cn

qiulihx@scu.edu.cn

Received Date: 9 October 2020
Revised Date: 7 December 2020
Accepted Date: 7 December 2020
Available Online: 11 December 2020

Figures(4)

The increasing incidence of osteoarthritis (OA) seriously affects life quality, posing a huge socioeconomic burden. Tissue engineering technology has become a hot topic in articular cartilage repair as one of the key treatment methods to alleviate OA. Hydrogel, one of the most commonly used scaffold materials, can provide a good extracellular matrix microenvironment for seed cells such as bone marrow mesenchymal stem cells (BMSCs), which can promote cartilage regeneration. However, the low homing rate of stem cells severely limits their role in promoting articular cartilage regeneration. Stromal cell-derived factor- 1α (SDF-1α) plays a crucial role in the activation, mobilization, homing, and migration of MSCs. Herein, a novel injectable chemotaxis hydrogel, composed of chitosan-based injectable hydrogel and embedding SDF-1α-loaded nanodroplets (PFP@NDs-PEG-SDF-1α) was designed and fabricated. The ultrasound was then used to augment the injectable chemotaxis hydrogel and promote the homing migration of BMSCs for OA cartilage repair. The effect of ultrasound augmenting injectable PFP@NDs-PEG-SDF-1α/hydrogel on the migration of BMSCs was verified in vitro and in vivo, which remarkably promotes stem cell homing and the repair of cartilage in the OA model. Therefore, the treatment strategy of ultrasound augmenting injectable chemotaxis hydrogel has a bright potential for OA articular cartilage repair.
- SDF-1α,
- Injectable hydrogel,
- Ultrasound,
- Osteoarthritis,
- Cartilage repair
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