Citation: Qunjie Bi, Xu Song, Ao Hu, Tianying Luo, Rongrong Jin, Hua Ai, Yu Nie. Magnetofection: Magic magnetic nanoparticles for efficient gene delivery[J]. Chinese Chemical Letters, ;2020, 31(12): 3041-3046. doi: 10.1016/j.cclet.2020.07.030 shu

Magnetofection: Magic magnetic nanoparticles for efficient gene delivery

Qunjie Bi ^a ,
Xu Song ^{b, *,} ,
Ao Hu ^a ,
Tianying Luo ^a ,
Rongrong Jin ^a ,
Hua Ai ^a ,
Yu Nie ^{a, *,}

a.
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China
b.
Institute of Regulatory Science for Medical Devices, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China

xusong2016@scu.edu.cn

nie_yu@scu.edu.cn

Received Date: 9 June 2020
Revised Date: 15 July 2020
Accepted Date: 15 July 2020
Available Online: 16 July 2020

Figures(5)

Magnetic nanoparticles (MNPs) have become a research hotspot and widely used in the biomedical field in recent decades due to their unique magnetic properties. This minireview summarizes the specific gene transfection of magnetic particles (magnetofection) during eversy dynamic process of gene delivery (gene binding, cellular uptake, endosomal escape, intracellular trafficking and in vivo targeting). Meanwhile, the synergistic biomedical application of magnetofection and the effects of MNPs have also been discussed, including magnetic resonance imaging (MRI), magnetic mediated hyperthermia (MMH), Fenton reaction and autophagy. Finally, the clinical prospect of magnetofection was briefly expected.
- Magnetic nanoparticles,
- Magentofection,
- Gene therapy,
- Biomedical applications,
- Combined therapy
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