Citation: Rui Cao, Wen Sun, Zheng Zhang, Xiaojing Li, Jianjun Du, Jiangli Fan, Xiaojun Peng. Protein nanoparticles containing Cu(II) and DOX for efficient chemodynamic therapy via self-generation of H₂O₂[J]. Chinese Chemical Letters, ;2020, 31(12): 3127-3130. doi: 10.1016/j.cclet.2020.06.031 shu

Protein nanoparticles containing Cu(II) and DOX for efficient chemodynamic therapy via self-generation of H₂O₂

State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China

sunwen@dlut.edu.cn

Received Date: 24 February 2020
Revised Date: 19 June 2020
Accepted Date: 23 June 2020
Available Online: 24 June 2020

Figures(5)

Chemodynamic therapy (CDT) refers to generating hydroxyl radical (^·OH) in tumor sites via hydrogen peroxide (H₂O₂) catalyzed by transition metal ions in cancer cells under acidic environment. However, H₂O₂ content is not enough for effective CDT, although H₂O₂ content in cancer cells is higher than that of normal cells. Herein, we synthesized DOX@BSA-Cu NPs (nanoparticles) for effective CDT by providing enhanced content of H₂O₂ in cancer cells. The results proved Cu²⁺ in NPs could be reduced to Cu⁺ by glutathione (GSH) and effectively converted H₂O₂ to ^·OH. Moreover, the loaded low-dose doxorubicin (DOX) in the NPs could improve the content of H₂O₂ and resulted in more efficient generation of ^·OH in cancer cells. Thus DOX@BSA-Cu NPs exhibited higher cytotoxicity to cancer cells. This research may provide new ideas for the further studies on more effective Cu(II)-based CDT nanoagents.
- Chemodyamic therapy,
- Doxorubicin,
- Hydrogen peroxide,
- Fenton-like reaction,
- Hydroxyl radical
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Protein nanoparticles containing Cu(II) and DOX for efficient chemodynamic therapy via self-generation of H2O2

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Protein nanoparticles containing Cu(II) and DOX for efficient chemodynamic therapy via self-generation of H₂O₂