Citation: Shifang Wen, Kuo Zhang, Yuan Li, Jiaqi Fan, Ziming Chen, Jingping Zhang, Hao Wang, Lei Wang. A self-assembling peptide targeting VEGF receptors to inhibit angiogenesis[J]. Chinese Chemical Letters, ;2020, 31(12): 3153-3157. doi: 10.1016/j.cclet.2020.03.077 shu

A self-assembling peptide targeting VEGF receptors to inhibit angiogenesis

Shifang Wen ^{a, b, 1} ,
Kuo Zhang ^{b, 1} ,
Yuan Li ^b ,
Jiaqi Fan ^b ,
Ziming Chen ^{a, b} ,
Jingping Zhang ^{a, *,} ,
Hao Wang ^b ,
Lei Wang ^{b, *,}

a.
Faculty of Chemistry, Northeast Normal University, Changchun 130024, China
b.
Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing 100190, China

zhangjp162@nenu.edu.cn

wanglei@nanoctr.cn

Received Date: 28 February 2020
Revised Date: 30 March 2020
Accepted Date: 30 March 2020
Available Online: 23 April 2020

Figures(5)

Vascular endothelial growth factor (VEGF)-vascular endothelial growth factor receptor (VEGFR) pathways are essential in tumor angiogenesis, growth and metastasis. Studies on anti-angiogenic therapy have been mostly focused on the blockage of VEGF-VEGFR pathways. We report an extracellularly transformable peptide-based nanomaterial to develop artificial extracellular matrix (ECM)-like networks for high-efficient blockage of natural VEGF-VEGFR interactions. The transformable peptide-based nanomaterial transforms from nanoparticles into nanofibers upon binding to VEGFR in solution. In addition, the transformable peptide-based nanomaterial forms ECM-like fibrous networks on VEGFR overexpressed cells, inhibiting the VEGF-VEGFR interactions and the subsequent angiogenesis. The tube formation is reduced by nearly 85.1% after treatment. This strategy shows excellent potential for anti-angiogenesis, and inhibition of tumor invasion and metastasis.
- Self-assembly,
- Peptide,
- VEGF,
- Angiogenesis,
- Biomimetic
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