Citation: Zeng Liming, Liao Zonglang, Li Wenwei, Yuan Qijuan, Wu Peng, Gu Zhipeng, Liu Zhongqiu, Liao Guochao. Non-covalent glycosylated gold nanoparticles/peptides nanovaccine as potential cancer vaccines[J]. Chinese Chemical Letters, ;2020, 31(5): 1162-1164. doi: 10.1016/j.cclet.2019.10.015 shu

Non-covalent glycosylated gold nanoparticles/peptides nanovaccine as potential cancer vaccines

Zeng Liming ^a ,
Liao Zonglang ^a ,
Li Wenwei ^a ,
Yuan Qijuan ^b ,
Wu Peng ^a ,
Gu Zhipeng ^b ,
Liu Zhongqiu ^a,*, ,
Liao Guochao ^a,*,

a.
Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
b.
School of Biomedical Engineering, Sun Yat-sen University, Guangzhou 510006, China

liuzq@gzucm.edu.cn

liao@gzucm.edu.cn

Received Date: 30 August 2019
Revised Date: 12 October 2019
Accepted Date: 14 October 2019
Available Online: 17 October 2019

Figures(2)

Herein, we firstly developed a non-covalent glycosylated gold nanoparticles/peptides nanovaccine which is assembled by β-cyclodextrin (β-CD) based host-guest recognitions. This nanovaccine can generate significant titers of antibodies and improve the therapeutic effect against melanoma, suggesting the immunogenicity of peptide antigens can be improved by loading with this carrier. The novel vaccine carrier provides a platform for the transport of various antigens especially T cell-independent antigens.
- Non-covalent,
- Glycosylation,
- Nanoparticles/peptides nanovaccine,
- β-Cyclodextrin,
- Host-guest recognitions,
- Cancer vaccines
1. [1]
  F. Zhang, Z. Li, B. Jia, J. Ding, et al., Sci. Rep. 9(2019) 3512. doi: 10.1038/s41598-019-40084-w
2. [2]
  I.S. Ganda, Q. Zhong, M. Hali, et al., Int. J. Pharm. 527(2017) 79-91. doi: 10.1016/j.ijpharm.2017.05.045
3. [3]
  U. Sahin, E. Derhovanessian, M. Miller, et al., Nature 547(2017) 222-226. doi: 10.1038/nature23003
4. [4]
  P.A. Ott, Z. Hu, D.B. Keskin, et al., Nature 547(2017) 217-221. doi: 10.1038/nature22991
5. [5]
  A. Tsuboi, N. Hashimoto, F. Fujiki, et al., Cancer Immunol. Immunother. 68(2019) 331-340. doi: 10.1007/s00262-018-2274-1
6. [6]
  N.K. Botelho, B.O. Tschumi, J.A. Hubbell, et al., Front. Immunol. 10(2019) 294. doi: 10.3389/fimmu.2019.00294
7. [7]
  Y. Narita, Y. Arakawa, F. Yamasaki, et al., Neuro. Oncol. 21(2018) 348-359.
8. [8]
  M. Luo, H. Wang, Z. Wang, et al., Nat. Nanotechnol. 12(2017) 648-654. doi: 10.1038/nnano.2017.52
9. [9]
  Y. Mi, C.C. Smith, F. Yang, et al., Adv. Mater. 30(2018) e1706098. doi: 10.1002/adma.201706098
10. [10]
  Z. Wang, W. Liu, J. Shi, N. Chen, C. Fan, Mater. Horiz. 5(2018) 344-362. doi: 10.1039/C7MH00991G
11. [11]
  R. Kuai, L.J. Ochyl, K.S. Bahjat, A. Schwendeman, J.J. Moon, Nat. Mater.16(2017) 489-496. doi: 10.1038/nmat4822
12. [12]
  A.W. Li, M.C. Sobral, S. Badrinath, et al., Nat. Mater. 17(2018) 528-534. doi: 10.1038/s41563-018-0028-2
13. [13]
  Y.P. Jia, B.Y. Ma, X.W. Wei, Z.Y. Qian, Chin. Chem. Lett. 28(2017) 691-702. doi: 10.1016/j.cclet.2017.01.021
14. [14]
  J. Chen, Y. Huang, X. Yang, et al., Anal. Chim. Acta 1023(2018) 89-95. doi: 10.1016/j.aca.2018.02.082
15. [15]
  Y. Liu, Y. Wang, F. Yu, et al., Chem. Commun. 53(2017) 9486-9489. doi: 10.1039/C7CC04386D
16. [16]
  Y. Liu, W. Zhang, Q. He, et al., Chem. Commun. 52(2016) 10886-10889. doi: 10.1039/C6CC04623A
17. [17]
  H. Wang, B. Yang, Y. Wang, F. Liu, S. Dong, Chem. Commun. 55(2019) 253-256. doi: 10.1039/C8CC07691J
18. [18]
  M. Vetro, D. Safari, S. Fallarini, et al., Nanomedicine 12(2017) 13-23. doi: 10.2217/nnm-2016-0306
19. [19]
  S. Kang, S. Ahn, J. Lee, et al., J. Control. Release 256(2017) 56-67. doi: 10.1016/j.jconrel.2017.04.024
20. [20]
  W. Lin, C. Yang, Z. Xue, et al., J. Colloid. Interf. Sci. 528(2018) 135-144. doi: 10.1016/j.jcis.2018.05.082
21. [21]
  N. Benne, J. van Duijn, J. Kuiper, W. Jiskoot, B. Slütter, J. Control. Release 234(2016) 124-134. doi: 10.1016/j.jconrel.2016.05.033
22. [22]
  H. Shelley, R.J. Babu, J. Pharm. Sci. 107(2018) 1741-1753. doi: 10.1016/j.xphs.2018.03.021
23. [23]
  Y. Bai, C.P. Liu, X. Song, L. Zhuo, W. Tian, Chem.-Asian J. 13(2018) 3903-3911. doi: 10.1002/asia.201801366
24. [24]
  M. Yu, Z. Liu, Y. Du, et al., ACS. Appl. Mater. Inter. 13(2019) 15103-15110.
25. [25]
  Z. Du, K. Ke, X. Chang, R. Dong, B. Ren, Langmuir 34(2018) 5606-5614. doi: 10.1021/acs.langmuir.8b00470
26. [26]
  R.J. Anderson, C.W. Tang, N.J. Daniels, et al., Nat. Chem. Biol.10(2014) 943-949. doi: 10.1038/nchembio.1640
27. [27]
  G. Liao, Z. Zhou, S. Suryawanshi, M.A. Mondal, Z. Guo, ACS. Central. Sci. 2(2016) 210-218. doi: 10.1021/acscentsci.5b00364
28. [28]
  O. Gasser, K.J. Sharples, C. Barrow, et al., ACS. Central. Sci. 67(2018) 285-298.
29. [29]
  S.Khamehchian, M.Nikkhah, R. Madani, S.Hosseinkhani, J. Biomed. Mater. Res. A 104 (2016) 2693 -2700.
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