Citation: Zhao Huan, Wang Meizhi, Chen Guodong, Hu Dan, Li Enqing, Qu Yibo, Zhou Libing, Guo Liangdong, Yao Xinsheng, Gao Hao. Dimericbiscognienynes B and C: New diisoprenyl-cyclohexene-type meroterpenoid dimers from Biscogniauxia sp.[J]. Chinese Chemical Letters, ;2019, 30(1): 51-54. doi: 10.1016/j.cclet.2018.05.019 shu

Dimericbiscognienynes B and C: New diisoprenyl-cyclohexene-type meroterpenoid dimers from Biscogniauxia sp.

Zhao Huan ^a,b,1 ,
Wang Meizhi ^c,1 ,
Chen Guodong ^a,, ,
Hu Dan ^a ,
Li Enqing ^b ,
Qu Yibo ^c ,
Zhou Libing ^c ,
Guo Liangdong ^d ,
Yao Xinsheng ^a ,
Gao Hao ^a,,

a.
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China
b.
College of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China
c.
Guangdong-Hongkong-Macau Institute of CNS Regeneration, Joint International Research Laboratory of CNS Regeneration, Jinan University, Guangzhou 510632, China
d.
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China

Corresponding author: Chen Guodong, chgdtong@163.com Gao Hao, tghao@jnu.edu.cn

Received Date: 8 April 2018
Revised Date: 7 May 2018
Accepted Date: 8 May 2018
Available Online: 9 January 2018

Figures(4)

Dimericbiscognienynes B and C (1 and 2), two new diisoprenyl-cyclohexene-type meroterpenoid dimers, were isolated from Biscogniauxia sp. 71-10-1-1. Their structures, including the absolute configurations, were determined by spectroscopic analyses and ECD experiments. Meroterpenoids are special natural products that originate from mixed terpenoid-nonterpenoid pathway. As a member of meroterpenoid family, diisoprenyl-cyclohexene/ane-type meroterpenoids composed of two isoprenyl chains (C5 unit) and a cyclohexene/ane moiety (C6 unit), featuring diverse skeleton structures with wide range of bioactivities. In these reported diisoprenyl-cyclohexene/ane-type meroterpenoids, only three dimers were identified. The discovery of the two new dimers added members of this rare class of meroterpenoids.
- Meroterpenoid,
- Dimer,
- Diisoprenyl-cyclohexene/ane-type,
- meroterpenoid,
- Diels-Alder reaction,
- Biscogniauxia sp.
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