Citation: Yi-Rou Jiang, Fu-Hua Sun, Xiao-Yong Zhou, Wei-Bo Kong, Xing-Yi Xie. Water dispersible hydroxyapatite nanoparticles functionalized by a family of aminoalkyl phosphates[J]. Chinese Chemical Letters, ;2015, 26(9): 1121-1128. doi: 10.1016/j.cclet.2015.04.035 shu

Water dispersible hydroxyapatite nanoparticles functionalized by a family of aminoalkyl phosphates

1.
Department of Polymeric Biomaterials and Artificial Organs, College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China

Corresponding author: Xing-Yi Xie,
Received Date: 25 February 2015
Available Online: 23 April 2015
Fund Project: This work was financially supported by the National Science Foundation of China (No. 50973069) (No. 50973069)the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (No. 20101561-3-3). (No. 20101561-3-3)

A series of aminoalkyl phosphates (AAP-n, with carbon number n ranging from 2 to 6) are used as surface modifiers to prepare hydroxyapatite hydrocolloids. The resulting nanoparticles (Cn-HA) possess a coreshell structure where an ionized layer of calcium-(AAP-n) complex [⁺H₃N-(CH₂)_n-OPO₃Ca] encapsulates each hydroxyapatite core. Long-term colloidal stability is achieved due to the electrostatic repulsion among the suspending particles. The incorporation of AAP-n results in a preferential crystal growth along c-axis, showing an increasing aspect ratio of particles from C2-HA to C6-HA. Preliminary cell culture using osteoblast-like MG63 cells shows no cytotoxicity associated with the as-prepared Cn-HA particles. The functional amino groups around the nanoparticles could be used to graft various organic chains to prepare homogeneous HA/polymer composites as bone grafting materials.
- Hydroxyapatite,
- Hydrocolloid,
- Aminoalkyl phosphate,
- Cytotoxicity
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沈阳化工大学材料科学与工程学院沈阳 110142