Citation: Sakineh Asghari, Nastaran Malekian, Roya Esmaeilpour, Mohammad Ahmadipour, Mojtaba Mohseni. Three-component synthesis and antibacterial evaluation of some novel 1,2-dihydroisoquinoline derivatives[J]. Chinese Chemical Letters, ;2014, 25(11): 1441-1444. doi: 10.1016/j.cclet.2014.05.047 shu

Three-component synthesis and antibacterial evaluation of some novel 1,2-dihydroisoquinoline derivatives

1.
a Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar 47416-95447, Iran;
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b Nano and Biotechnology Research Group, University of Mazandaran, Babolsar 47416-95447, Iran;
3.
c Department of Microbiology, Faculty of Science, University of Mazandaran, Babolsar 47416-95447, Iran

Corresponding author: Sakineh Asghari,
Received Date: 14 April 2014
Available Online: 19 May 2014

Isoquinoline reacts with dialkyl acetylenedicarboxylates in the presence of kojic acid or 8-hydroxyquinoline to generate 1,2-dihydroisoquinoline derivatives. The simplicity, mild reaction conditions and high yields of products make it an interesting process compared to other approaches. The compounds have been analyzed for antibacterial activity against Gram negative and Gram positive bacteria. The results indicated that 1,2-dihydroisoquinolines derived from kojic acid are effective against all of the studied bacteria especially against Bacillus subtilis, while the products obtained from 8-hydroxyquinoline are active only against Gram positive bacteria.
- Kojic acid,
- 8-Hydroxyquinolone,
- Dialkyl acetylenedicarboxylates,
- 1,2-Dihydroisoquinoline,
- Isoquinoline,
- Antibacterial activity
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