Citation: Xiang Bo Wang, Lin He, Teng Yue Jian, Song Ye. Cyclic phosphoric acid catalyzed one-pot, four-component synthesis of 1,2,4,5-tetrasubstituted imidazoles[J]. Chinese Chemical Letters, ;2012, 23(1): 13-16. doi: 10.1016/j.cclet.2011.09.018 shu

Cyclic phosphoric acid catalyzed one-pot, four-component synthesis of 1,2,4,5-tetrasubstituted imidazoles

a Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan and School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832000, China;
b Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

Received Date: 26 May 2011

Fund Project: We are grateful to CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences for generous financial support.

Cyclic phosphoric acid catalyzed one-pot, four component reactions of benzil, aldehydes, priminary amines and ammonium acetate in refluxing ethanol were developed, giving highly substituted imidazoles in excellent yield.
- Cyclic phosphoric acid,
- Multicomponent reactions,
- Tetrasubstituted imidazoles
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