Citation:
Lin Li, Sheng Hai Chang, Jun Feng Xiang, Qian Li, Huan Huan Liang, Ya Lin Tang, Ying Fang Liu. NMR identification of anti-influenza lead compound targeting at PAC subunit of H5N1 polymerase[J]. Chinese Chemical Letters,
;2012, 23(1): 89-92.
doi:
10.1016/j.cclet.2011.09.006
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PAC subunit from avian influenza (H5N1) viral RNA polymerase was used in this work as a target in the screening for anti-influenza agents from licorice-derived compounds. As a result, 18β-glycyrrhetinic acid was suggested to be PAC ligand by flexible docking, and was then confirmed by relaxation-edited NMR. The result of ApG primer extension assay indicated that this PAC ligand can inhibit the polymerase activity, and thus may potentially be valuable as anti-influenza lead compound. This work validated the possibility of screening polymerase inhibitors by using PAC as a target, and provided a starting point for the further discovery of new anti-influenza drugs.
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