引用本文:
Li Chen, Wen Qiu, Jia Tang, Zhi Feng Wang, Shu Ying He. Synthesis and bioactivity of novel nitric oxide-releasing ursolic acid derivatives[J]. Chinese Chemical Letters,
2011, 22(4): 413-416.
doi:
10.1016/j.cclet.2010.10.036
Citation: Li Chen, Wen Qiu, Jia Tang, Zhi Feng Wang, Shu Ying He. Synthesis and bioactivity of novel nitric oxide-releasing ursolic acid derivatives[J]. Chinese Chemical Letters, 2011, 22(4): 413-416. doi: 10.1016/j.cclet.2010.10.036
Citation: Li Chen, Wen Qiu, Jia Tang, Zhi Feng Wang, Shu Ying He. Synthesis and bioactivity of novel nitric oxide-releasing ursolic acid derivatives[J]. Chinese Chemical Letters, 2011, 22(4): 413-416. doi: 10.1016/j.cclet.2010.10.036
Synthesis and bioactivity of novel nitric oxide-releasing ursolic acid derivatives
摘要:
A series of furoxan-based novel nitric oxide-donating ursolic acid (UA) derivatives (7a-f) were synthesized, and their cytotoxic activities against HepG2 cells in vitro were evaluated by MTT method. It was found that 7a-d and 7f showed more potent cytotoxic activities than control 5-fluorouracil and UA.
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关键词:
- Ursolic acid
- / Nitric oxide
- / Furoxan
- / Cytotoxic activity
English
Synthesis and bioactivity of novel nitric oxide-releasing ursolic acid derivatives
Abstract:
A series of furoxan-based novel nitric oxide-donating ursolic acid (UA) derivatives (7a-f) were synthesized, and their cytotoxic activities against HepG2 cells in vitro were evaluated by MTT method. It was found that 7a-d and 7f showed more potent cytotoxic activities than control 5-fluorouracil and UA.
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Key words:
- Ursolic acid
- / Nitric oxide
- / Furoxan
- / Cytotoxic activity
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