Citation: Li Qiang Fu, Xin Sheng Guo, Xin Liu, Hui Li He, Yu Lin Wang, Yu She Yang. Synthesis and antibacterial activity of C-2 (S)-substituted pleuromutilin derivatives[J]. Chinese Chemical Letters, ;2010, 21(5): 507-510. doi: 10.1016/j.cclet.2010.01.001 shu

Synthesis and antibacterial activity of C-2 (S)-substituted pleuromutilin derivatives

a Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;
b School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110015, China

Received Date: 12 November 2009

In order to probe the effect of C-2 (S)-substituted groups in the antibacterial activity, a series of novel C-2 (S)-substituted pleuromutilin analogues of SB-225586 were synthesized and evaluated for their in vitro antibacterial activity. The results of antibacterial activities indicated that C-2 (S)-substituted pleuromutilin derivatives retained appreciable antibacterial activity, and the 2-fluorination compounds 6a and 6b are more potent than the corresponding 2-hydroxylation analogues 7a and 7b.
- Synthesis,
- Pleuromutilin,
- C-2 (S)-substituted,
- Antimicrobial activity
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