引用本文:
Shuai Jian Ni, Hui Bin Zhang, Wen Long Huang, Jin Pei Zhou, Hai Qian. Solid phase synthesis of fatty acid modified glucagon-like peptide-1 (7-36) amide under thermal and controlled microwave irradiation[J]. Chinese Chemical Letters,
2010, 21(1): 27-30.
doi:
10.1016/j.cclet.2009.08.007
Citation: Shuai Jian Ni, Hui Bin Zhang, Wen Long Huang, Jin Pei Zhou, Hai Qian. Solid phase synthesis of fatty acid modified glucagon-like peptide-1 (7-36) amide under thermal and controlled microwave irradiation[J]. Chinese Chemical Letters, 2010, 21(1): 27-30. doi: 10.1016/j.cclet.2009.08.007
Citation: Shuai Jian Ni, Hui Bin Zhang, Wen Long Huang, Jin Pei Zhou, Hai Qian. Solid phase synthesis of fatty acid modified glucagon-like peptide-1 (7-36) amide under thermal and controlled microwave irradiation[J]. Chinese Chemical Letters, 2010, 21(1): 27-30. doi: 10.1016/j.cclet.2009.08.007
Solid phase synthesis of fatty acid modified glucagon-like peptide-1 (7-36) amide under thermal and controlled microwave irradiation
摘要:
Fatty acid modified glucagon-like peptide-1(7-36) amide was synthesized efficiently on Rink-Amide-MBHA resin by microwave-assisted solid phase method. The method of thermal and controlled microwave irradiation provided impressive enhancements in product yield, selectivity, and reaction rate. The coupling time was dramatically decreased to 6 min, and the desired products were obtained in high yield and purity.
English
Solid phase synthesis of fatty acid modified glucagon-like peptide-1 (7-36) amide under thermal and controlled microwave irradiation
Abstract:
Fatty acid modified glucagon-like peptide-1(7-36) amide was synthesized efficiently on Rink-Amide-MBHA resin by microwave-assisted solid phase method. The method of thermal and controlled microwave irradiation provided impressive enhancements in product yield, selectivity, and reaction rate. The coupling time was dramatically decreased to 6 min, and the desired products were obtained in high yield and purity.
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Key words:
- Glucagon-like peptide-1
- / GLP-1
- / Microwave
- / Solid phase
- / Fatty acid modification
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