Citation: Wei Gang Huang, Jing Ya Li, Yu Luo, Jia Li, Wei Lu. Synthesis of tanshinone ⅡA analogues and their inhibitory activities against Cdc25 phosphatases[J]. Chinese Chemical Letters, ;2009, 20(12): 1461-1464. doi: 10.1016/j.cclet.2009.07.008 shu

Synthesis of tanshinone ⅡA analogues and their inhibitory activities against Cdc25 phosphatases

Wei Gang Huang ^b, ,
Jing Ya Li ^b ,
Yu Luo ^a ,
Jia Li ^b ,
Wei Lu ^a

a Department of Chemistry, East China Normal University, Shanghai 200062, China;
b The National Center for Drugs Screening, Shanghai Institute of Materia Medica, SIBS, Chinese Academy of Sciences, Shanghai 201203, China

Received Date: 5 May 2009

Fund Project: We gratefully acknowledge the financial support by program for New Century Excellent Talents in University (NCET)and National Natural Science Foundation of China (No.305722321).And we also thank Lab of Organic Functional Moleculesthe Sino-French Institute of ECNU for supports.

Two series of tanshinone ⅡA derivatives were synthesized and evaluated for their antitumor activities as Cdc25 phosphatase inhibitors.Most of them demonstrated potent Cdc25 inhibitory activity and powerful cytotoxicity against A549 tumor cell line,producing IC₅₀ values in very low micromolar range.At last, the preliminary SAR was discussed.
- Tanshinone ⅡA,
- Cdc25 phosphatases,
- Synthesis,
- Antitumor
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