引用本文:
Huai Ren Pan, Hai Jun Zhu, Zhong Rong Song, Xu Dong Zhang, Huai Cao. Molecular modeling of epsilon RNA from hepatitis B virus[J]. Chinese Chemical Letters,
2009, 20(10): 1263-1266.
doi:
10.1016/j.cclet.2009.05.018
Citation: Huai Ren Pan, Hai Jun Zhu, Zhong Rong Song, Xu Dong Zhang, Huai Cao. Molecular modeling of epsilon RNA from hepatitis B virus[J]. Chinese Chemical Letters, 2009, 20(10): 1263-1266. doi: 10.1016/j.cclet.2009.05.018
Citation: Huai Ren Pan, Hai Jun Zhu, Zhong Rong Song, Xu Dong Zhang, Huai Cao. Molecular modeling of epsilon RNA from hepatitis B virus[J]. Chinese Chemical Letters, 2009, 20(10): 1263-1266. doi: 10.1016/j.cclet.2009.05.018
Molecular modeling of epsilon RNA from hepatitis B virus
摘要:
An initial model of the HBV epsilon RNA was built by the Biopolymer module of Insight Ⅱ.While its three-dimensional structure was obtained through structure optimization based on molecular dynamics simulation, the two active sites were found.A comparison with the experimental result indicated that the active sites may be the binding sites of the epsilon RNA in the RT-epsilon interaction.The result will be helpful to further discussion about the mechanism of RT-epsilon interaction and the study of HBV genome replication.
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关键词:
- HBV
- / Epsilon RNA
- / RT-epsilon interaction
- / Molecular dynamics
English
Molecular modeling of epsilon RNA from hepatitis B virus
Abstract:
An initial model of the HBV epsilon RNA was built by the Biopolymer module of Insight Ⅱ.While its three-dimensional structure was obtained through structure optimization based on molecular dynamics simulation, the two active sites were found.A comparison with the experimental result indicated that the active sites may be the binding sites of the epsilon RNA in the RT-epsilon interaction.The result will be helpful to further discussion about the mechanism of RT-epsilon interaction and the study of HBV genome replication.
-
Key words:
- HBV
- / Epsilon RNA
- / RT-epsilon interaction
- / Molecular dynamics
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